{"title":"Influence of obesity on skeletal muscle contractile dysfunction in aging","authors":"Hiroaki Eshima","doi":"10.7600/jpfsm.9.199","DOIUrl":null,"url":null,"abstract":"Obesity and aging reduce skeletal muscle contractile function, which represents a reduction in muscle quality. Dysfunction of muscle contraction may contribute to a greater risk for diabetes, cardiovascular diseases, and cancer; therefore, the synergistic effects of obesity and aging on muscle function may exacerbate morbidity and mortality. However, evidence di-rectly examining the synergistic effects of obesity and aging on muscle contractile function is lacking and controversial. We recently demonstrated that diet-induced obesity significantly exacerbates contractile dysfunction in aged skeletal muscle. The focus of this review is the effects of obesity on muscle contractile dysfunction in skeletal muscle, particularly during aging.","PeriodicalId":55847,"journal":{"name":"Journal of Physical Fitness and Sports Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Physical Fitness and Sports Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7600/jpfsm.9.199","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Obesity and aging reduce skeletal muscle contractile function, which represents a reduction in muscle quality. Dysfunction of muscle contraction may contribute to a greater risk for diabetes, cardiovascular diseases, and cancer; therefore, the synergistic effects of obesity and aging on muscle function may exacerbate morbidity and mortality. However, evidence di-rectly examining the synergistic effects of obesity and aging on muscle contractile function is lacking and controversial. We recently demonstrated that diet-induced obesity significantly exacerbates contractile dysfunction in aged skeletal muscle. The focus of this review is the effects of obesity on muscle contractile dysfunction in skeletal muscle, particularly during aging.