Bevacizumab for malignant pleural effusion in ovarian clear cell carcinoma: a case report

IF 0.5 4区 医学 Q4 OBSTETRICS & GYNECOLOGY European journal of gynaecological oncology Pub Date : 2021-06-15 DOI:10.31083/J.EJGO.2021.03.2338
Di Wu, Yanqin Zhang, Jinwei Miao
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引用次数: 1

Abstract

Objective: Malignant pleural effusion (MPE) is a major problem associated with late phase of epithelial ovarian cancer for which an optimum treatment consensus has yet to be determined. Although bevacizumab (Bev), a VEGF ligand inhibitor, has been shown to effectively control MPE, the clinical benefit of half-dose Bev treatment to control MPE remains unclear. Methods: We describe a patient with platinum-sensitive ovarian clear cell cancer (OCCC) and symptomatic MPE for whom tumor markers increased after one cycle of paclitaxel and carboplatin chemotherapy. After switching to five cycles of Bev plus paclitaxel/carboplatin chemotherapy, we observed the disappearance of MPE. Conclusion: The half-dose Bev therapy may be an effective treatment for MPE in OCCC. However, further investigation is still warranted to evaluate the therapeutic effectiveness of Bev.
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贝伐单抗治疗卵巢透明细胞癌恶性胸腔积液1例
目的:恶性胸腔积液(MPE)是与晚期上皮性卵巢癌相关的主要问题,其最佳治疗共识尚未确定。尽管VEGF配体抑制剂贝伐单抗(bevacizumab, Bev)已被证明能有效控制MPE,但半剂量Bev治疗控制MPE的临床益处尚不清楚。方法:我们描述了一个铂敏感卵巢透明细胞癌(OCCC)和症状性MPE患者,其肿瘤标志物在紫杉醇和卡铂化疗一个周期后升高。切换到5个周期的Bev +紫杉醇/卡铂化疗后,我们观察到MPE消失。结论:半剂量贝弗可能是治疗OCCC MPE的有效方法。然而,Bev的治疗效果仍有待进一步研究。
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来源期刊
自引率
25.00%
发文量
58
审稿时长
1 months
期刊介绍: EJGO is dedicated to publishing editorial articles in the Distinguished Expert Series and original research papers, case reports, letters to the Editor, book reviews, and newsletters. The Journal was founded in 1980 the second gynaecologic oncology hyperspecialization Journal in the world. Its aim is the diffusion of scientific, clinical and practical progress, and knowledge in female neoplastic diseases in an interdisciplinary approach among gynaecologists, oncologists, radiotherapists, surgeons, chemotherapists, pathologists, epidemiologists, and so on.
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