Ali Kharazmkia, Javad Ghasemian Yadegari, M. Mohammadian, Rehman Ali, H. Mahmoudvand
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引用次数: 0
Abstract
Introduction: The present work aimed to assess the anti-parasitic effects of limonene (LMN) against Giardia lamblia trophozoites and cysts. Methods: Anti-Giardia activities of LMN (25, 50, and 100 μg/mL) were assessed against G. lamblia cysts and trophozoites for 15-360 minutes. The effects of LMN on the apoptosis stimulation G. lamblia parasites were determined by colorimetric protease assay. Results: Giardia trophozoites were more sensitive to LMN than cysts. The best effect of LMN was seen at 100 μg/mL. LMN markedly triggered caspase-3 activity by 10.2%, 25.3%, and 36.1%, respectively (P < 0.001). Conclusion: We found the potent in vitro anti-giardia activity of LMN against G. lamblia parasites with the maximum activity at 50 and 100 μg/mL. However, additional surveys are necessary to reveal the specific efficacy, mechanisms, and safety of LMN.
期刊介绍：
Journal of Herbmed Pharmacology (J Herbmed Pharmacol) is the intersection between medicinal plants and pharmacology. This international journal publishes manuscripts in the fields of medicinal plants, pharmacology and therapeutic. This journal aims to reach all relevant national and international medical institutions and persons in electronic version free of charge. J Herbmed Pharmacol has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of diseases. A further aim of this journal is to emphasize and strengthen the link between herbalists and pharmacologists. In addition, J Herbmed Pharmacol welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical pharmacology. Contributions in any of these formats are invited for editorial consideration following peer review by at least two experts in the field.
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