Chronic wounds: pathological characteristics and their stem cell-based therapies

Q1 Medicine Engineered regeneration Pub Date : 2023-03-01 DOI:10.1016/j.engreg.2022.11.004

Xiangyi Wu , Haofang Zhu , Ye Xu , Bin Kong , Qian Tan

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引用次数: 1

Abstract

Chronic wounds are characterized by prolonged healing processes and poor prognoses, which have substantially impacted human health and daily life. Traditional treatment strategies have various limitations and drawbacks. Therefore, fully effective therapeutic approaches remain urgently needed. Stem cell (SC)-based therapies have drawn significant attention for their abilities of immunomodulation and pro-regeneration. It has been demonstrated that stem cells (SCs) can improve angiogenesis, collagen deposition, and hair rejuvenation, thus facilitating wound healing. In addition, attempts were performed to facilitate the cell survival, function, retention, and engraftment of the delivered SCs. In this review, we first introduce the pathological process involved in chronic wound healing. Following that, the mechanism of SCs in promoting chronic wound repair is discussed in detail. Then, we highlight recent SC-based therapies for chronic wound repair developments. Finally, we present our views on the remaining challenges and future trends of SC-based therapies for chronic wound treatment.

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慢性创伤的病理特征及其干细胞治疗

慢性伤口的特点是愈合过程长，预后差，严重影响了人类健康和日常生活。传统的治疗策略有各种局限性和缺点。因此，迫切需要完全有效的治疗方法。基于干细胞(SC)的治疗方法因其免疫调节和促进再生的能力而受到广泛关注。已经证明干细胞(SCs)可以促进血管生成、胶原沉积和头发再生，从而促进伤口愈合。此外，还进行了促进细胞存活、功能、保留和移植的尝试。在这篇综述中，我们首先介绍了慢性伤口愈合的病理过程。随后，详细讨论了SCs促进慢性伤口修复的机制。然后，我们强调了最近基于sc的慢性伤口修复疗法的发展。最后，我们提出了我们对sc为基础的慢性伤口治疗的挑战和未来趋势的看法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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