Recent advancement of nanostructured materials: a compatible therapy of tissue engineering and drug delivery system

IF 3.1 3区化学 Q2 POLYMER SCIENCE Polymer Bulletin Pub Date : 2023-09-07 DOI:10.1007/s00289-023-04983-3

Jagabandhu Bag, Swarupananda Mukherjee, Dipanjan Karati

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Abstract

Research into drug delivery and tissue engineering (TE) has made great strides in the current era because of its limitless potential to enhance human health. In the meantime, the advancement of nanotechnology offers chances to categorize, control, and arrange orderly arrangements of materials at the nanoscale ranking. Biomaterials with the nanoscale organization have been applied to TE as artificial matrices and controlled-release drug reservoirs. Drug delivery systems may be created with precise control over composition, morphology, size, and shape. Their surface characteristics might be changed to improve solubility, immune compatibility, and cellular absorption. Current drug delivery methods include drawbacks such as poor bioavailability, ineffective targeting, and possible cytotoxicity. Dendrimers, nanoparticles, nanocapsules, nanotubes, and nano gels are auspicious and adaptable nano-scale medicine transportation methods. Small-molecule medications and numerous biomacromolecules can be delivered using them. Current TE scaffolds differ from earlier ones because they are based on something other than hydrolytically degradable macroporous materials. Methods highlight nanoscale topography resembling the natural extracellular matrix (ECM) to influence cell activities and tissue creation. Researchers were inspired to create nanofibrous congeners using electrospinning or self-assembly after realizing that the natural ECM is a multifunctional nanocomposite. It has been demonstrated that nanocrystal-containing nanocomposites stimulate active bone formation. TE and drug delivery are areas that are closely connected. The objective of TE is to achieve controlled distribution of mammalian cells, which can be seen as a specific example of medication delivery. Consequently, the effectiveness of TE will be improved by the controlled release of therapeutic elements. Both the medication delivery systems and the scaffolds used in TE must be biocompatible and biodegradable from a material standpoint. By creating biomaterials with regulated properties, the biotic capabilities of encapsulated pharmaceuticals and cells may be significantly improved. The latest advancements in using nanostructured ingredients for TE and medication delivery are summarised in this study.

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纳米结构材料的最新进展：组织工程与药物递送系统的相容性治疗

药物输送和组织工程（TE）研究在当今时代取得了长足的进步，因为它在增进人类健康方面具有无限的潜力。与此同时，纳米技术的发展为纳米级材料的分类、控制和有序排列提供了机会。具有纳米级组织结构的生物材料已被应用到 TE 中，作为人工基质和控释药物库。通过对成分、形态、大小和形状的精确控制，可以创建药物释放系统。它们的表面特征可以通过改变来提高溶解度、免疫相容性和细胞吸收率。目前的给药方法存在生物利用率低、靶向性差和可能的细胞毒性等缺点。树枝状聚合物、纳米颗粒、纳米胶囊、纳米管和纳米凝胶是具有良好适应性的纳米级药物输送方法。小分子药物和多种生物大分子都可以用它们来输送。目前的 TE 支架与早期的支架不同，因为它们不是基于可水解降解的大孔材料。这些方法突出了与天然细胞外基质（ECM）相似的纳米级形貌，以影响细胞活动和组织生成。在意识到天然 ECM 是一种多功能纳米复合材料后，研究人员受到启发，利用电纺丝或自组装技术制造纳米纤维同系物。研究表明，含纳米晶体的纳米复合材料可刺激活性骨形成。TE 和药物输送是密切相关的领域。TE 的目的是实现哺乳动物细胞的可控分布，这可以看作是给药的一个具体例子。因此，通过控制治疗元素的释放，可以提高 TE 的有效性。从材料的角度来看，TE 中使用的给药系统和支架都必须具有生物相容性和可生物降解性。通过创造具有可调节特性的生物材料，可大大提高封装药物和细胞的生物能力。本研究总结了将纳米结构成分用于 TE 和给药的最新进展。

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来源期刊

Polymer Bulletin 化学-高分子科学

CiteScore

6.00

自引率

6.20%

发文量

审稿时长

5.5 months

期刊介绍： "Polymer Bulletin" is a comprehensive academic journal on polymer science founded in 1988. It was founded under the initiative of the late Mr. Wang Baoren, a famous Chinese chemist and educator. This journal is co-sponsored by the Chinese Chemical Society, the Institute of Chemistry, and the Chinese Academy of Sciences and is supervised by the China Association for Science and Technology. It is a core journal and is publicly distributed at home and abroad. "Polymer Bulletin" is a monthly magazine with multiple columns, including a project application guide, outlook, review, research papers, highlight reviews, polymer education and teaching, information sharing, interviews, polymer science popularization, etc. The journal is included in the CSCD Chinese Science Citation Database. It serves as the source journal for Chinese scientific and technological paper statistics and the source journal of Peking University's "Overview of Chinese Core Journals."