Preoperative neurocognitive function as an independent survival prognostic marker in primary glioblastoma.

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2023-05-11 eCollection Date: 2023-12-01 DOI:10.1093/nop/npad027

Evangelia Liouta, Christos Koutsarnakis, Spyridon Komaitis, Aristotelis V Kalyvas, Evangelos Drosos, Juan M García-Gómez, Javier Juan-Albarracín, Vasileios Katsaros, Lampis Stavrinou, George Stranjalis

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引用次数: 1

Abstract

Background: Aim of the present study is to investigate whether preoperative neurocognitive status is prognostically associated with overall survival (OS) in newly diagnosed glioblastoma (GBM) patients.

Methods: Ninety patients with dominant-hemisphere IDH-wild-type GBM were assessed by Mini Mental Status Exam (MMSE), Trail Making Test (TMT) A and B parts, and Control Word Association Test (COWAT) phonemic and semantic subtests. Demographics, Karnofsky Performance Scale, tumor parameters, type of surgery, and adjuvant therapy data were available for patients.

Results: According to Cox proportional hazards model the neurocognitive variables of TMT B (P < .01), COWAT semantic subset (P < .05), and the MMSE (P < .01) were found significantly associated with survival prediction. From all other factors, only tumor volume and operation type (debulking vs biopsy) showed a statistical association (P < .05) with survival prediction. Kaplan Meier Long rank test showed statistical significance (P < .01) between unimpaired and impaired groups for TMT B, with median survival for the unimpaired group 26 months and 10 months for the impaired group, for COWAT semantic (P < .01) with median survival 23 months and 12 months, respectively and for MMSE (P < .01) with medial survival 19 and 12 months respectively.

Conclusions: Our study demonstrates that neurocognitive status at baseline-prior to treatment-is an independent prognostic factor for OS in wild-type GBM patients, adding another prognostic tool to assist physicians in selecting the best treatment plan.

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术前神经认知功能作为原发性胶质母细胞瘤的独立生存预后标志物

本研究的目的是调查新诊断的胶质母细胞瘤（GBM）患者术前神经认知状态是否与总生存率（OS）具有预后相关性。采用简易精神状态检查（MMSE）、追踪测试（TMT）A和B部分以及对照词联想测试（COWAT）音素和语义亚测验对90例显性半球IDH野生型GBM患者进行评估。患者可获得人口学、卡诺夫斯基表现量表（KPS）、肿瘤参数、手术类型和辅助治疗数据。根据Cox比例危险模型，发现TMT B（p<0.01）、COWAT语义子集（p<0.05）和MMSE（p<0.01）的神经认知变量与生存预测显著相关。从所有其他因素来看，只有肿瘤体积和手术类型（减瘤与活检）与生存预测具有统计学相关性（p＜0.05）。Kaplan-Meier-Long秩检验显示，TMT B在未受损组和受损组之间具有统计学意义（p<0.01），未受损组的中位生存期分别为26个月和10个月，COWAT语义组（p<0.01）的中位存活期分别为23个月和12个月，MMSE组（p<0.01。我们的研究表明，治疗前基线时的神经认知状态是野生型GBM患者OS的一个独立预后因素，为帮助医生选择最佳治疗方案增加了另一个预后工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.