Xin Du, B. Hong, Qiang Zhao, Yongpeng Ji, Yong Yang, Ning Zhang
{"title":"Progress in detection and clinical application of circulating tumor cells in renal cell carcinoma","authors":"Xin Du, B. Hong, Qiang Zhao, Yongpeng Ji, Yong Yang, Ning Zhang","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.016","DOIUrl":null,"url":null,"abstract":"Renal cell carcinoma is one of the common malignant tumors in genitourinary cancer. 20%-30% of patients have distant metastases. However, current biomarkers used for diagnosis, recurrence monitoring, and prognosis assessment are still uncertain. Circulating tumor cells (CTCs) are tumor cells that are detached from the primary tumor or metastases, and invade and presenting in peripheral blood vessels. Therefore, CTCs is regarded as a key step in the process of tumor metastasis. However, current studies on CTCs of renal cell carcinoma are facing with problems such as inconsistent detection methods and limited clinical applications. This article reviews the progress in the detection and clinical application of CTCs of renal cell carcinoma. \n \nKey words: \nCarcinoma, renal cell; Circulating tumor cells (CTCs); Biomarker","PeriodicalId":10343,"journal":{"name":"中华泌尿外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华泌尿外科杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.016","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Renal cell carcinoma is one of the common malignant tumors in genitourinary cancer. 20%-30% of patients have distant metastases. However, current biomarkers used for diagnosis, recurrence monitoring, and prognosis assessment are still uncertain. Circulating tumor cells (CTCs) are tumor cells that are detached from the primary tumor or metastases, and invade and presenting in peripheral blood vessels. Therefore, CTCs is regarded as a key step in the process of tumor metastasis. However, current studies on CTCs of renal cell carcinoma are facing with problems such as inconsistent detection methods and limited clinical applications. This article reviews the progress in the detection and clinical application of CTCs of renal cell carcinoma.
Key words:
Carcinoma, renal cell; Circulating tumor cells (CTCs); Biomarker
期刊介绍:
Chinese Journal of Urology (monthly) was founded in 1980. It is a publicly issued academic journal supervised by the China Association for Science and Technology and sponsored by the Chinese Medical Association. It mainly publishes original research papers, reviews and comments in this field. This journal mainly reports on the latest scientific research results and clinical diagnosis and treatment experience in the professional field of urology at home and abroad, as well as basic theoretical research results closely related to clinical practice.
The journal has columns such as treatises, abstracts of treatises, experimental studies, case reports, experience exchanges, reviews, reviews, lectures, etc.
Chinese Journal of Urology has been included in well-known databases such as Peking University Journal (Chinese Journal of Humanities and Social Sciences), CSCD Chinese Science Citation Database Source Journal (including extended version), and also included in American Chemical Abstracts (CA). The journal has been rated as a quality journal by the Association for Science and Technology and as an excellent journal by the Chinese Medical Association.