The protective effect of both platelet rich plasma and electro-acupuncture on acute pancreatitis caused by tetracycline in rat's model

Abstract

Background and objectives

Acute pancreatitis causes about 230,000 of the world's hospitalizations yearly, with mortality rates for severe cases reaching 30%. Drugs are responsible for a large percentage of acute pancreatitis incidents, Based on these health risks, this study investigated the role of platelet-rich plasma and electro-acupuncture as protective therapies against tetracycline pancreatic injury effects.

Materials and methods

This study was carried out on 60 rats after they were divided into 4 subgroups (one control and three treatment groups).

Results

The histological and biochemical examination of the pancreas were shown a promising result about the protective effects of the platelet-rich plasma therapies in which the growth factors may result in the induction of pancreatic cell regeneration and decreased inflammation Also, it found that electro-acupuncture is a promising type of therapy to protect the pancreas from tetracycline toxic effects.

Conclusion

The present study's positive outcomes are hoped to contribute to a decline in the tremendous morbidity and mortality rates from drug-induced pancreatic injury around the world.