Predisposing factors of cerebral edema in Pediatric Diabetic Ketoacidosis: A systematic review

IF 0.3 Q4 PEDIATRICS Journal of Pediatrics Review Pub Date : 2022-03-06 DOI:10.32598/jpr.10.1.994.1
H. Jafari, Pooneh Dadashian, J. Ghaffari, D. Zamanfar
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Abstract

Background: diabetic ketoacidosis (DKA) is not the most common acute complication of type 1 diabetes in children and adolescents, But the cerebral edema caused by it is the most common cause of death in children with DKA. Objectives: The purpose of this study was to systematically review the literature to describe of the Predisposing factors of cerebral edema in Pediatric Diabetic Ketoacidosis. Methods: sex international databases of Wiley, Medline, Scopus, web of science, ProQuest and Cochrane Library s, and three domestic databases, including SID, Magiran and Iranmedex were searched for relevant studies. Then, articles with inclusion criteria and related to the objectives of this study were reviewed. Results: These studies have identified several risk factors for cerebral edema, some of which are related to the severity of the disease at admission and some of which are related to treatment. Conclusion: Preventing DKA is the only reliable way to prevent cerebral edema until the causes of this life-threatening complication are fully understood.
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儿童糖尿病酮症酸中毒脑水肿的易发因素:系统综述
背景:糖尿病酮症酸中毒(DKA)不是儿童和青少年1型糖尿病最常见的急性并发症,但其引起的脑水肿是DKA儿童最常见的死亡原因。目的:本研究的目的是系统地回顾文献,以描述儿童糖尿病酮症酸中毒脑水肿的易发因素。方法:检索Wiley、Medline、Scopus、web of science、ProQuest和Cochrane Library的国际性数据库,以及SID、Magiran和Iranmedex三个国内数据库进行相关研究。然后,对纳入标准和与本研究目标相关的文章进行了综述。结果:这些研究已经确定了脑水肿的几个危险因素,其中一些与入院时疾病的严重程度有关,另一些与治疗有关。结论:在完全了解这种危及生命的并发症的原因之前,预防DKA是预防脑水肿的唯一可靠方法。
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审稿时长
8 weeks
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