The Application of Nanozymes in the Diagnosis and Treatment of TUMOR: A Review

IF 0.8 Q4 MATERIALS SCIENCE, BIOMATERIALS Nano Life Pub Date : 2021-10-25 DOI:10.1142/s1793984421410063
Wenbo Yang, Hongzhi Hu, Peng Wang, Wei Huang, Zengwu Shao
{"title":"The Application of Nanozymes in the Diagnosis and Treatment of TUMOR: A Review","authors":"Wenbo Yang, Hongzhi Hu, Peng Wang, Wei Huang, Zengwu Shao","doi":"10.1142/s1793984421410063","DOIUrl":null,"url":null,"abstract":"Nanozyme is a kind of nanomaterial with simulated enzyme activity. Due to its high catalytic efficiency, better stability and modifiability, the role of nanozymes in medicine, especially in the diagnosis and treatment of tumors, is receiving more and more attention. Nanozymes usually contain metals and are often used in combination with drugs or antigens/antibodies to become multifunctional materials for the diagnosis and treatment of tumors. At present, the detailed synthesis, classification and function of nanozymes need to be supplemented. In our review, we introduce the research status, synthesis and classification of nanozymes roundly. Then we summarized and introduced some characteristic nanozymes according to their functions, mainly including tumor diagnosis, tumor therapy, tumor surgical adjuvant therapy and multifunctional complexes. We believe that many breakthroughs have been made in the research of nanozymes, and more and more multifunctional nanozymes have been studied. However, there are still some shortcomings in the current research on nanozymes such as the lack of solutions to some of the insufficient properties of nanoparticles, like spontaneous aggregation, nonspecific phagocytosis, etc. At the same time, the catalytic reaction is relatively simple, which limits the further application of nanozyme. In our review, we made our own comments and prospects on the diagnostic, therapeutic and application of nanozymes. In the future, nanozymes will play an increasingly important role in the diagnosis and treatment of tumors due to their potential modifiability and versatility as well as their increasingly perfect physicochemical properties.","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2021-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Life","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1142/s1793984421410063","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0

Abstract

Nanozyme is a kind of nanomaterial with simulated enzyme activity. Due to its high catalytic efficiency, better stability and modifiability, the role of nanozymes in medicine, especially in the diagnosis and treatment of tumors, is receiving more and more attention. Nanozymes usually contain metals and are often used in combination with drugs or antigens/antibodies to become multifunctional materials for the diagnosis and treatment of tumors. At present, the detailed synthesis, classification and function of nanozymes need to be supplemented. In our review, we introduce the research status, synthesis and classification of nanozymes roundly. Then we summarized and introduced some characteristic nanozymes according to their functions, mainly including tumor diagnosis, tumor therapy, tumor surgical adjuvant therapy and multifunctional complexes. We believe that many breakthroughs have been made in the research of nanozymes, and more and more multifunctional nanozymes have been studied. However, there are still some shortcomings in the current research on nanozymes such as the lack of solutions to some of the insufficient properties of nanoparticles, like spontaneous aggregation, nonspecific phagocytosis, etc. At the same time, the catalytic reaction is relatively simple, which limits the further application of nanozyme. In our review, we made our own comments and prospects on the diagnostic, therapeutic and application of nanozymes. In the future, nanozymes will play an increasingly important role in the diagnosis and treatment of tumors due to their potential modifiability and versatility as well as their increasingly perfect physicochemical properties.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
纳米酶在肿瘤诊断和治疗中的应用综述
纳米酶是一种具有模拟酶活性的纳米材料。由于其催化效率高、稳定性和可修饰性好,纳米酶在医学中的作用,特别是在肿瘤诊断和治疗中的作用越来越受到重视。纳米酶通常含有金属,并经常与药物或抗原/抗体结合使用,成为诊断和治疗肿瘤的多功能材料。目前,纳米酶的详细合成、分类和功能还有待补充。综述了纳米酶的研究现状、合成方法及分类。然后根据纳米酶的功能对其进行了总结和介绍,主要包括肿瘤诊断、肿瘤治疗、肿瘤手术辅助治疗和多功能复合物。我们相信,纳米酶的研究已经取得了许多突破,越来越多的多功能纳米酶被研究。然而,目前对纳米酶的研究仍存在一些不足,如缺乏解决纳米颗粒某些性质不足的方案,如自发聚集、非特异性吞噬等。同时,催化反应相对简单,限制了纳米酶的进一步应用。在我们的综述中,我们对纳米酶的诊断、治疗和应用发表了自己的评论和展望。未来,纳米酶由于其潜在的可修饰性和多功能性以及日益完善的理化性质,将在肿瘤的诊断和治疗中发挥越来越重要的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Nano Life
Nano Life MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
0.70
自引率
12.50%
发文量
14
期刊最新文献
Nanotherapeutic Approaches for the Treatment of Rheumatoid Arthritis Taming of Organic Pollutants Using Covalent-Organic-Framework-based Materials: Challenges and Future Prospects HSP90 antisense oligonucleotide enhances the inhibitory effect of photothermal therapy on triple-negative breast cancer cells Amoxicillin Degradation and Antimutagenic Potential of Phytofabricated Silver Nanoparticles Doped Polyurethane Membrane for Wastewater Treatment A Critical Review on Nanotechnology: A Technique in Cancer Detection and Prophylaxis
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1