Correlation between Carotid Artery Mean Intima-Media Thickness and brain Natriuretic Peptide in Patients with Psoriasis.

Q3 Medicine Journal of Psoriasis and Psoriatic Arthritis Pub Date : 2022-10-01 Epub Date: 2022-08-08 DOI:10.1177/24755303221118037

Nasim Niknezhad, Mohammad Shahidi-Dadras, Fateme Rajabi, Hamidreza Haghighat Khah, Nakisa Niknejad, Shima Younespour

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Abstract

Background: Numerous studies have documented an association between psoriasis and subclinical atherosclerosis.

Objective: We aimed to investigate the effects of psoriasis on the levels of N-terminal prohormone B type natriuretic peptide (NT-proBNP) and clarify whether this factor correlates with the evaluations of subclinical atherosclerosis, measured with mean intima-media thickness (MIMT) of the carotid artery.

Methods: Sixty-one psoriatic patients and sixty-one healthy, age and sex-matched volunteers were enrolled. MIMT was assessed via ultrasonography and serum NT-proBNP level were measured by electrochemiluminescence.

Results: Both NT-proBNP and MIMT were significantly higher in psoriasis patients. This remained true even after controlling for the effects of age and gender. MIMT was positively correlated with age and serum NT-proBNP level in both groups.

Conclusions: In conclusion, NT-proBNP levels may be used as a predictor of subclinical atherosclerosis in patients with psoriasis.

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银屑病患者颈动脉平均内膜-中膜厚度与脑利钠肽的相关性

背景大量研究已经证实牛皮癣与亚临床动脉粥样硬化之间存在关联。目的研究银屑病对n端激素原B型利钠肽(NT-proBNP)水平的影响，并通过测量颈动脉平均内膜-中膜厚度(MIMT)来明确该因素是否与亚临床动脉粥样硬化的评估相关。方法选取61名银屑病患者和61名年龄、性别匹配的健康志愿者。采用超声法检测血清NT-proBNP水平，电化学发光法检测血清NT-proBNP水平。结果银屑病患者NT-proBNP和MIMT均显著增高。即使在控制了年龄和性别的影响后，这一结论仍然成立。两组患者MIMT均与年龄、血清NT-proBNP水平呈正相关。结论NT-proBNP水平可作为银屑病患者亚临床动脉粥样硬化的预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Psoriasis and Psoriatic Arthritis Medicine-Dermatology

CiteScore

1.30

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0.00%

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