Significance of fluid retention, body mass index, and weight loss in patients with advanced cancer

JCSM clinical reports Pub Date : 2020-06-25 DOI:10.1002/crt2.23

Koji Amano, Isseki Maeda, Hiroto Ishiki, Tomofumi Miura, Yutaka Hatano, Kiyofumi Oya, Akihiro Sakashita, Satoko Ito, Yusuke Hiratsuka, Tatsuya Morita, Masanori Mori

{"title":"Significance of fluid retention, body mass index, and weight loss in patients with advanced cancer","authors":"Koji Amano, Isseki Maeda, Hiroto Ishiki, Tomofumi Miura, Yutaka Hatano, Kiyofumi Oya, Akihiro Sakashita, Satoko Ito, Yusuke Hiratsuka, Tatsuya Morita, Masanori Mori","doi":"10.1002/crt2.23","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Few studies have investigated the relationship between body mass index (BMI) and mortality or evaluated the prognostic validity of a grading system incorporating BMI and weight loss in Asian cancer patients. We conducted a study to investigate characteristics according to BMI and to confirm the prognostic validity of BMI and the grading system.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This study involved a secondary analysis of a prospective cohort study. Subjects were divided into six BMI groups and five grades according to the grading system. Characteristics were compared between the six groups. We conducted time-to-event analyses using the Kaplan–Meier method, log-rank test, and univariate and multivariate Cox regression analyses.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 1094 patients were classified into six BMI groups: <17 (<i>n</i> = 244), 17–18.4 (<i>n</i> = 211), 18.5–19.9 (<i>n</i> = 192), 20–21.9 (<i>n</i> = 196), 22–24.9 (<i>n</i> = 161), and 25 ≤ (<i>n</i> = 90). Regarding oedema, the prevalence increased with BMI, being 70% the 25 ≤ group. The prevalence of pleural effusion and ascites were the highest in the 25 ≤ group. Median survival ranged between 18 and 22 days in the six groups. No significant differences were observed in survival rates among the six BMI groups (log rank <i>P</i> = 0.83). No significant differences were observed in survival rates among the five grades (log rank <i>P</i> = 0.25).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>The prevalence of fluid retention is high in patients with advanced cancer. BMI and weight loss appear to lose their prognostic significance among them.</p>\n </section>\n </div>","PeriodicalId":73543,"journal":{"name":"JCSM clinical reports","volume":"5 3","pages":"69-78"},"PeriodicalIF":0.0000,"publicationDate":"2020-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/crt2.23","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JCSM clinical reports","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/crt2.23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 4

Abstract

Background

Few studies have investigated the relationship between body mass index (BMI) and mortality or evaluated the prognostic validity of a grading system incorporating BMI and weight loss in Asian cancer patients. We conducted a study to investigate characteristics according to BMI and to confirm the prognostic validity of BMI and the grading system.

Methods

This study involved a secondary analysis of a prospective cohort study. Subjects were divided into six BMI groups and five grades according to the grading system. Characteristics were compared between the six groups. We conducted time-to-event analyses using the Kaplan–Meier method, log-rank test, and univariate and multivariate Cox regression analyses.

Results

A total of 1094 patients were classified into six BMI groups: <17 (n = 244), 17–18.4 (n = 211), 18.5–19.9 (n = 192), 20–21.9 (n = 196), 22–24.9 (n = 161), and 25 ≤ (n = 90). Regarding oedema, the prevalence increased with BMI, being 70% the 25 ≤ group. The prevalence of pleural effusion and ascites were the highest in the 25 ≤ group. Median survival ranged between 18 and 22 days in the six groups. No significant differences were observed in survival rates among the six BMI groups (log rank P = 0.83). No significant differences were observed in survival rates among the five grades (log rank P = 0.25).

Conclusions

The prevalence of fluid retention is high in patients with advanced cancer. BMI and weight loss appear to lose their prognostic significance among them.

Abstract Image