HDNC (1-hydroxy-5, 7-dimethoxy-2 naphthalene-carboxaldehyde) for rapid recovery of gastric damage in incision wound model of rats

Q1 Medicine Wound Medicine Pub Date : 2017-09-01 DOI:10.1016/j.wndm.2017.06.002

Lubna Azmi , Ila Shukla , Shyam Sundar Gupta , Shravan Kumar Paswan , Padam Kant , Ch.V. Rao

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Abstract

HDNC (1-hydroxy-5, 7-dimethoxy-2 naphthalene-carboxaldehyde) is a bioactive compound derived from Aegle marmelos (Rutaceae, ‘Bael’). The current study was conducted to conclude the effect of HDNC on mechanical properties and collagen content of stomach and duodenal wounds in rats. This experiment included wound creation in rumen (non-glandular part) & corpus (oxyntic) part of stomach and duodenum. These wounds were analyzed after 0, 5, 15 & 30 days post-operation. HDNC treatment found to improve the mechanical strength of healing wounds of stomach and duodenum. Breaking strength and breaking energy were also augmented in presence of HDNC. Healing process was slower in initial post-operative phase (after 5 days). However in later days wound strength enhanced drastically. Direct relation was observed between total collagen content and mechanical strength. These findings point towards that the amplification of mechanical strength and collagen content in wounds has been the outcome of HDNC treatment.

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HDNC（1-羟基-5,7-二甲氧基-2萘甲醛）对大鼠切口创伤模型胃损伤的快速恢复作用

HDNC(1-羟基- 5,7 -二甲氧基-2萘-甲醛)是一种生物活性化合物，从蜜瓜(芸香科，' Bael ')中提取。本研究旨在探讨HDNC对大鼠胃、十二指肠创伤组织力学性能及胶原蛋白含量的影响。本实验包括瘤胃(非腺体部分)创面;胃和十二指肠的主体(氧合)部分。这些伤口分别在0、5、15分钟后进行分析。术后30天。发现HDNC治疗可提高胃、十二指肠伤口愈合的机械强度。HDNC的存在也增加了断裂强度和断裂能。术后初期(5天后)愈合过程较慢。然而，在后来的日子里，伤口的强度急剧提高。总胶原蛋白含量与机械强度有直接关系。这些发现表明，HDNC治疗的结果是伤口中机械强度和胶原蛋白含量的增加。

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Wound Medicine Medicine-Surgery

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