Is the prognostic nutritional index a predictor of Covid-19 related hospitalizations and mortality?

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-03-01 DOI:10.4314/mmj.v35i1.4

Muhammed Emin Demirkol, Gulali Aktas, Murat Alisik, Ozgur Mehmet Yis, Musa Kaya, Derya Kocadag

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Abstract

Introduction: Prognostic nutritional index (PNI) is a novel inflammation marker that useful in predicting prognosis of certain conditions. We aimed to study PNI of the outpatient and inpatient subjects with established Covid-19 and also aimed to compare PNI of deceased and survived Covid-19 patients.

Methods: The patients with Covid-19 whom presented to outpatient or inpatient clinics of Abant Izzet Baysal University Hospital were enrolled to the study. PNI levels of the inpatients and outpatients, deceased and survived were compared. PNI values of deceased and survived in inpatients were also compared.

Results: Study population was consisted of 4419 subjects (2907 outpatients and 1512 inpatients). PNI of the inpatient (41.55 (36.42-47.1)) group was significantly lower than the PNI of the outpatient (51.95 (47.95-55.75)) subjects (p<0.001). The sensitivity and specificity of PNI (≤46.2 level) in determination of requirement inpatient treatment were 71.2% and 83.5%, respectively. PNI of the deceased patients (37(33.39-40.86)) was lower than the PNI of the survivors (50.45(45.6-54.65)), (p<0.001). The sensitivity and specificity of PNI at ≤44.55 level in determining mortality were 89.22% and 78.87%, respectively.

Conclusion: We suggest that PNI could serve as a reliable prognostic index in covid-19 patients. Reduced level of PNI should alert physicians since it is associated with need for hospitalization and mortality in this population.

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预后营养指数是Covid-19相关住院和死亡率的预测因子吗?

预后营养指数（PNI）是一种新的炎症标志物，可用于预测某些疾病的预后。我们旨在研究已确诊新冠肺炎的门诊和住院受试者的PNI，并旨在比较新冠肺炎死亡和存活患者的PNI。方法对在Abant Izzet Baysal大学医院门诊或住院的新冠肺炎患者进行研究。比较住院患者和门诊患者、死亡患者和存活患者的PNI水平。比较了住院病人中死亡和存活的PNI值。结果研究人群包括4419名受试者（2907名门诊患者和1512名住院患者）。住院组（41.55（36.42-47.1））的PNI显著低于门诊组（51.95（47.95-55.75））（p＜0.001）。PNI（≤46.2）在确定住院治疗需求方面的敏感性和特异性分别为71.2%和83.5%。死亡患者的PNI（37（33.39-40.86））低于存活患者的PNI50.45（45.6-54.65）（p＜0.001）。PNI在≤44.55水平下测定死亡率的敏感性和特异性分别为89.22%和78.87%。结论PNI可作为新冠肺炎患者的可靠预后指标。PNI水平的降低应该提醒医生，因为它与该人群的住院需求和死亡率有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.