An Introduction to the International Journal of Particle Therapy's Special Issue on Particle Therapy for Head and Neck Malignancies

Abstract

Particle therapy has emerged as a standard-of-care treatment option in the management of head and neck malignancies owing to its unique physical and biologic properties that lead to improved clinical outcomes. Likewise, the value of particle therapy in the management of head and neck tumors has rapidly evolved over the past decade, and head and neck cancer management currently represents one of the most common indications for the use of proton therapy. It is therefore my privilege to introduce this special IJPT Particle Therapy for Head and Neck Malignancies issue, which offers 33 articles by renowned international authors knowledgeable in head and neck cancer management, making it, to date, the most definitive guide to this new standard of care. The research presented herein expands our knowledge of the biologic enhancement effect of proton therapy, the physical properties that require unique and complex treatment planning approaches, and the resulting improvement in long-term clinical outcomes. Further clarity has been provided on the use of advanced Monte Carlo and LET-based treatment planning and quality assurance methods for emerging treatment centers, thereby minimizing the risk of unnecessary side effects and complications. Additional opportunities are offered for personalization of particle therapy through combining its biologic enhancement effects with concurrent systemic therapy. From pediatrics to adults, the issue seeks to advance health policy and improve patient access with model-based selection, activity-based costing, cost-effectiveness, financial toxicity, and work productivity outcomes. I would like to dedicate this special issue to our head and neck cancer patients worldwide who have participated in the clinical trials and research protocols that have resulted in these publications, thereby advancing our knowledge and standard of care for future patients. like dedicate this special issue to my parents and family, who have constant support to see this project to completion.