Transcriptome analysis of blastocysts acquiring implantation competency in mice

Abstract

Blastocyst activation, referring to the blastocyst acquiring the implantation competency, is the determining factor for implantation into the receptive uterus. It involves the process of embryonic cell differentiation to contact and initiate dialog with the uterine cells. Before the application of -omics approaches to this biological event, only the cellular morphological changes and a small number of molecules were known to regulate this process. This review aims to discuss the recent exploration for global molecular changes during the blastocyst activation in mouse model, based on a transcriptional evaluation strategy.