HIF-1α and VEGF polymorphisms and systemic lupus erythematosus susceptibility

IF 0.8 Q4 GENETICS & HEREDITY Meta Gene Pub Date : 2021-12-01 DOI:10.1016/j.mgene.2021.100982

Mohsen Saravani , Mahnaz Sandoughi , Zohreh Heidary , Ghasem Ebrahimi , Solmaz Mirzamohammadi , Mohammad Haddadi , Mohammad Hadi Nematollahi

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引用次数: 1

Abstract

Background

Hypoxia-inducible factor-1α (HIF-1α) and its downstream gene, vascular endothelial factor (VEGF), play an important role in modulating the immune system function and consequently alternation the susceptibility to systemic lupus erythematosus (SLE) disease.

Objective

The present study aimed to investigate the effect of the HIF-1α and VEGF gene polymorphisms and the susceptibility to SLE.

Methods

The 140 patients and 150 healthy age and gender-matched people as a control group participated in the study. The PCR-RFLP method was used for genotyping.

Results

No remarkable differences in allele frequencies of HIF-1α (rs11549465) and VEGF (rs699947) were seen between the SLE and control groups. The frequencies of CT genotype of the HIF-1α (rs11549465) and CA genotype of VEGF (rs699947) in the control were significantly higher than SLE group (OR = 0.53; 95% CI = 0.32–0.53; p = 0.014; OR = 0.57;95% CI = 0.33–0.99; p = 0.046, resp.). In the case of HIF-1α (C111A) polymorphism, the CA and AA variants were not found.

Conclusion

HIF-1α (rs11549465) CT and VEGF (rs699947) CA genotypes were identified as protective factors for SLE. However, additional studies are required to confirm the association between HIF-1α and VEGF polymorphisms and SLE.

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HIF-1α和VEGF多态性与系统性红斑狼疮易感性的关系

缺氧诱导因子-1α (HIF-1α)及其下游基因血管内皮因子(VEGF)在调节免疫系统功能，从而改变对系统性红斑狼疮(SLE)疾病的易感性方面发挥重要作用。目的探讨HIF-1α和VEGF基因多态性对SLE易感性的影响。方法140例患者和150例年龄、性别匹配的健康人作为对照组。采用PCR-RFLP方法进行基因分型。结果SLE患者HIF-1α (rs11549465)和VEGF (rs699947)等位基因频率与对照组无显著差异。对照组HIF-1α CT基因型(rs11549465)和VEGF CA基因型(rs699947)的频率显著高于SLE组(OR = 0.53;95% ci = 0.32-0.53;p = 0.014;Or = 0.57;95% ci = 0.33-0.99;P = 0.046，相对而言)。在HIF-1α (C111A)多态性的情况下，未发现CA和AA变异。结论hif -1α (rs11549465) CT和VEGF (rs699947) CA基因型是SLE的保护因子。然而，还需要进一步的研究来证实HIF-1α和VEGF多态性与SLE之间的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.