AdoMet Synergistically Enhances the Chemotherapeutic Action of Cisplatin and Improves Drug Efficacy in JHU-SCC-011 Laryngeal Squamous Cell Carcinoma

Abstract

Laryngeal squamous cell carcinoma (LSCC), an epithelial tumor that originates from larynx, is highly aggressive and more than 150.000 new cases are diagnosed each year [1,2]. Alcohol consumption, tobacco use and human papilloma virus (HPV) infections are the main risk factors for these types of cancer [3,4]. The main treatment options are surgery, radiotherapy, targeted therapy, and chemotherapy [1,2]. Despite significant progress in finding potential therapeutic targets to improve survival, mortality is still high. Several studies have focused on the discovery of new molecules, obtained from natural compounds, that demonstrate anticancer and anti-proliferation effect and can be used in combination with conventional chemotherapy agents for LSCC treatment. Among natural compounds, our research group focused its interest on S-adenosyl-L-methionine (AdoMet), a naturally occurring sulfur-containing nucleoside found ubiquitously in all living cells where it functions as the main biological methyl donor. The role of AdoMet in various cellular processes, such as proliferation, differentiation, cell cycle regulation, cell migration and apoptosis has been Abstract