Effects of atrazine on the endocrinology and histoarchitecture of the testes in African Catfish, Clarias gariepinus (Burchell, 1822)

IF 1.1 4区 环境科学与生态学 Q3 MARINE & FRESHWATER BIOLOGY African Journal of Aquatic Science Pub Date : 2021-05-09 DOI:10.2989/16085914.2021.1890541
P. Opute, I. Oboh, JE Asouzu, N. Pilani, E. Mbajiorgu
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引用次数: 1

Abstract

Aquatic ecosystems often receive a wide spectrum of pollutants introduced directly or indirectly. The herbicide atrazine, an endocrine disrupting chemical (EDC), frequently contaminates potable water supplies and aquatic ecosystems. Studies suggest atrazine induced alterations in the neuroendocrine system along the hypothalamus-pituitary-gonadal (HPG) axis. This study investigated the effects of atrazine (0, 2.5, 25, 250 and 500 μg l−1 for 28 days of exposure) on testosterone (TST) and prolactin (PRL) levels, testes histology and seminiferous tubular morphometry of Clarias gariepinus juveniles. TST and PRL significantly decreased in all the 28 days atrazine exposed groups. Histologically, the testes showed vacuolated and sloughing of basal germinal epithelium in the treated groups. A high correlation between testicular biopsy score counts and results of seminiferous tubular morphometry was also observed. Findings from this study confirm that atrazine is an EDC in fish that alters reproductive dysfunction by targeting the HPG axis, as evidenced by its effects on the investigated reproductive hormones. Furthermore, atrazine disrupted the histoarchitectural components of the testes, which may interfere with spermatogenesis and therefore impair the reproductive functions of the fish.
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阿特拉津对非洲鲶鱼睾丸内分泌学和组织结构的影响(Burchell, 1822)
水生生态系统经常受到各种直接或间接引入的污染物。除草剂阿特拉津是一种内分泌干扰化学物质,经常污染饮用水供应和水生生态系统。研究表明,阿特拉津诱导沿下丘脑-垂体-性腺(HPG)轴的神经内分泌系统发生改变。本研究研究了阿特拉津(0、2.5、25、250和500 μg l−1)暴露28 d后对鸡尾Clarias gariepinus幼鱼睾丸激素(TST)和催乳素(PRL)水平、睾丸组织学和精管形态的影响。所有阿特拉津暴露组的TST和PRL均显著降低。组织学上,治疗组睾丸基底生发上皮呈空泡化和脱落。睾丸活检计数与精管形态测量结果之间也存在高度相关性。本研究结果证实,阿特拉津是鱼类体内的一种EDC,通过靶向HPG轴改变生殖功能障碍,其对所研究的生殖激素的影响证明了这一点。此外,阿特拉津破坏了睾丸的组织结构成分,这可能会干扰精子的发生,从而损害鱼的生殖功能。
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来源期刊
African Journal of Aquatic Science
African Journal of Aquatic Science MARINE & FRESHWATER BIOLOGY-
CiteScore
3.90
自引率
7.10%
发文量
31
审稿时长
>12 weeks
期刊介绍: The African Journal of Aquatic Science is an international journal devoted to the study of the aquatic sciences, covering all African inland and estuarine waters. The Journal publishes peer-reviewed original scientific papers and short articles in all the aquatic science fields including limnology, hydrobiology, ecology, conservation, biomonitoring, management, water quality, ecotoxicology, biological interactions, physical properties and human impacts on African aquatic systems.
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