{"title":"Gut dysbiosis in severe acute malnutrition is not an immaturity: The irreversible quantitative-qualitative paradigm shift","authors":"Matthieu Million , Didier Raoult","doi":"10.1016/j.humic.2019.100067","DOIUrl":null,"url":null,"abstract":"<div><p>We read with interest a work of the Gordon team reporting a gut microbiota immaturity in severe acute malnutrition. However, almost all gut microbes are found in colostrum and breast milk, including methanogenic <em>Archaea.</em> These <em>Archaea</em> are detected in baby’s stomach and in 40% healthy control children but are lost in severe acute malnutrition. <em>Bifidobacterium breve</em> and <em>Bifidobacterium longum</em> are other exceptions to immaturity. These errors are critical because they are a key to treat and cure these children. We argue that milk probiotics including <em>Bifidobacterium, Lactobacillus</em> and <em>Archaea</em> could be the next revolution in the management of malnutrition.</p></div>","PeriodicalId":37790,"journal":{"name":"Human Microbiome Journal","volume":"15 ","pages":"Article 100067"},"PeriodicalIF":0.0000,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.humic.2019.100067","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Microbiome Journal","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452231719300168","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 2
Abstract
We read with interest a work of the Gordon team reporting a gut microbiota immaturity in severe acute malnutrition. However, almost all gut microbes are found in colostrum and breast milk, including methanogenic Archaea. These Archaea are detected in baby’s stomach and in 40% healthy control children but are lost in severe acute malnutrition. Bifidobacterium breve and Bifidobacterium longum are other exceptions to immaturity. These errors are critical because they are a key to treat and cure these children. We argue that milk probiotics including Bifidobacterium, Lactobacillus and Archaea could be the next revolution in the management of malnutrition.
期刊介绍：
The innumerable microbes living in and on our bodies are known to affect human wellbeing, but our knowledge of their role is still at the very early stages of understanding. Human Microbiome is a new open access journal dedicated to research on the impact of the microbiome on human health and disease. The journal will publish original research, reviews, comments, human microbe descriptions and genome, and letters. Topics covered will include: the repertoire of human-associated microbes, therapeutic intervention, pathophysiology, experimental models, physiological, geographical, and pathological changes, and technical reports; genomic, metabolomic, transcriptomic, and culturomic approaches are welcome.
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