Synthesis of the Key Saccharide Fragments of the Glucuronic Acid-Containing Repeat Unit of Pentosan Polysulfate, a Heparin Sulfate Mimetic

IF 2 Q2 CHEMISTRY, ORGANIC SynOpen Pub Date : 2023-05-08 DOI:10.1055/a-2126-0346
M. Banwell, Sarah Marshall, J. Ward, B. Schwartz
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Abstract

Suitably protected mono- and di-saccharide residues associated with the glucuronic acid-containing repeat unit (1) related to pentosan polysulfate have been prepared. The stereo-controlled coupling, using trichloroacetimidate chemistry, of certain of these is also described and the

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硫酸肝素模拟物戊聚糖多硫酸酯葡萄糖醛酸重复单元关键糖片段的合成
已经制备了与戊聚糖聚硫酸酯相关的含葡萄糖醛酸重复单元(1)相关的适当保护的单糖和双糖残基。本文还描述了利用三氯乙酸酯化学对其中某些化合物的立体控制偶联
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来源期刊
SynOpen
SynOpen CHEMISTRY, ORGANIC-
CiteScore
2.30
自引率
4.00%
发文量
35
审稿时长
6 weeks
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