Evaluation of Chewing Gums Containing Natural Products on Salivary Concentrations of Streptococcus mutans in Children

IF 0.4 Q4 PHARMACOLOGY & PHARMACY Journal of Young Pharmacists Pub Date : 2023-01-01 DOI:10.5530/097515050561
E. Fraga, E. M. R. Neto, Fernanda Maria Teófilo Campos, Manoel Patrick da Silva Cavalcante, Frederico Augusto Amorim, Luiz Filipe Barbosa Martins, Antônia Kelly Martins Sousa, Ana Cristina de Mello Fiallos, M. Mimica
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Abstract

Background: Streptococcus mutans ( S. mutans ) are present in the bacterial biofilm involved in the onset and progression of childhood caries, favoring acid production and dental demineralization. Sugar consumption favors the high incidence of caries in childhood, from 5 to 12 years old. A chewable lozenge incorporated with natural antimicrobial agents of recognized potency, such as red propolis and xylitol, would be an adjuvant to control caries. Materials and Methods: This is a randomized, placebo-controlled, cross-sectional clinical trial. 40 participants were divided into four groups: Placebo (group I), Red Propolis 2.5% (group II); Red propolis 6.4% (group III) and Xylitol 15% (group IV). They had saliva collected at different times of the trial for analysis of antimicrobial action. The study was registered with REBEC. Results: In the group I there were variations before and after the administration of the tablets, but no statistical significance, in relation to the group II it was found a significant reduction in the salivary concentration of S. mutans in all salivary dilutions (34,25% - 63,65%), fact observed with the group III (38,42% - 45,02%) and group IV (50,72% - 42,92%). Conclusion: With encouraging results, further studies are needed for a longitudinal follow-up, being a low-cost alternative with anticariogenic potential.
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含天然产物的口香糖对儿童唾液中变形链球菌浓度的评价
背景:变形链球菌(S. mutans)存在于细菌生物膜中,参与儿童龋齿的发生和发展,有利于酸的产生和牙齿脱矿。在5岁至12岁的儿童时期,糖的摄入有利于龋齿的高发。咀嚼含片中加入了公认的天然抗菌剂,如红蜂胶和木糖醇,将是控制龋齿的辅助剂。材料和方法:这是一项随机、安慰剂对照、横断面临床试验。40名参与者被分为四组:安慰剂组(I组),2.5%红蜂胶组(II组);红色蜂胶6.4% (III组),木糖醇15% (IV组)。在试验的不同时间采集唾液进行抗菌作用分析。该研究已在REBEC注册。结果:1组在给药前后均有差异,但无统计学意义;与2组相比,3组(38、42% ~ 45、02%)和4组(50、72% ~ 42、92%)的唾液中变形链球菌浓度均显著降低(34、25% ~ 63、65%)。结论:随着令人鼓舞的结果,需要进一步的纵向随访研究,这是一种具有抗肿瘤潜力的低成本替代方法。
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来源期刊
Journal of Young Pharmacists
Journal of Young Pharmacists PHARMACOLOGY & PHARMACY-
自引率
25.00%
发文量
94
期刊介绍: Journal of Young Pharmacists - An official journal of InPharm Association and supported by Phcog.Net.. J Young Pharm is a peer-reviewed open-access Quarterly journal featuring research articles of exceptional significance in all areas of Pharmaceutical Sciences. J Young Pharm provides comprehensive coverage of issues affecting Pharmaceutical education and Career.
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