Cellular landscaping of exosomal miRNAs in cancer metastasis: From chemoresistance to prognostic markers

IF 2 Q3 ONCOLOGY Advances in cancer biology - metastasis Pub Date : 2022-10-01 DOI:10.1016/j.adcanc.2022.100050

Rahul Bhattacharjee , Priya Mitra , Nitin Gupta , Sony Sharma , Vipendra Kumar Singh , Nobendu Mukerjee , Archna Dhasmana , Rohit Gundamaraju

{"title":"Cellular landscaping of exosomal miRNAs in cancer metastasis: From chemoresistance to prognostic markers","authors":"Rahul Bhattacharjee , Priya Mitra , Nitin Gupta , Sony Sharma , Vipendra Kumar Singh , Nobendu Mukerjee , Archna Dhasmana , Rohit Gundamaraju","doi":"10.1016/j.adcanc.2022.100050","DOIUrl":null,"url":null,"abstract":"<div><p>Exosomes are cargos facilitating the transport of miRNAs across cancer cells. Exosomal miRNA has been an area of interest in recent times due to their triple role in cancer proliferation. The current review discusses the triple role of exosomal miRNAs and proposes its application in diagnosis as a prognostic marker. Exosomal miRNAs are miRNAs found inside the exosomal structure of 30–150 nm of an extracellular vesicle. The synthesis and biogenesis of these exosomal miRNA involve an endosomal sorting complex required for transport which releases miRNAs and relevant proteins to cause tumor heterogeneity, drug resistance, and cancer metastasis. Herein, we have highlighted the role of exosomal miRNAs in both drug resistance and cancer metastasis. Additionally, we have elucidated the impact of exosomal miRNAs upon host immunity, which will provide us with the idea of host immune rejection. Furthermore, we have elaborated the clinical importance of exosomal miRNAs as a prognostic marker.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"5 ","pages":"Article 100050"},"PeriodicalIF":2.0000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667394022000247/pdfft?md5=9af9d4ecb2f30ec5c2c8acee6130fc00&pid=1-s2.0-S2667394022000247-main.pdf","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in cancer biology - metastasis","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667394022000247","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 4

Abstract

Exosomes are cargos facilitating the transport of miRNAs across cancer cells. Exosomal miRNA has been an area of interest in recent times due to their triple role in cancer proliferation. The current review discusses the triple role of exosomal miRNAs and proposes its application in diagnosis as a prognostic marker. Exosomal miRNAs are miRNAs found inside the exosomal structure of 30–150 nm of an extracellular vesicle. The synthesis and biogenesis of these exosomal miRNA involve an endosomal sorting complex required for transport which releases miRNAs and relevant proteins to cause tumor heterogeneity, drug resistance, and cancer metastasis. Herein, we have highlighted the role of exosomal miRNAs in both drug resistance and cancer metastasis. Additionally, we have elucidated the impact of exosomal miRNAs upon host immunity, which will provide us with the idea of host immune rejection. Furthermore, we have elaborated the clinical importance of exosomal miRNAs as a prognostic marker.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

肿瘤转移中外泌体mirna的细胞景观:从化疗耐药到预后标志物

外泌体是促进mirna在癌细胞间运输的货物。由于外泌体miRNA在癌症增殖中的三重作用，近年来一直是人们感兴趣的领域。本文讨论了外泌体mirna的三重作用，并提出了其作为预后标志物在诊断中的应用。外泌体mirna是在细胞外囊泡30 - 150nm外泌体结构内发现的mirna。这些外泌体miRNA的合成和生物发生涉及运输所需的内体分选复合体，该复合体释放miRNA和相关蛋白，导致肿瘤异质性、耐药和癌症转移。在此，我们强调了外泌体mirna在耐药和癌症转移中的作用。此外，我们已经阐明了外泌体mirna对宿主免疫的影响，这将为我们提供宿主免疫排斥的想法。此外，我们还详细阐述了外泌体mirna作为预后标志物的临床重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊