Serum Levels of NT-Pro BNP in Patients with Preeclampsia

IF 1.5 Q3 PERIPHERAL VASCULAR DISEASE Integrated Blood Pressure Control Pub Date : 2022-04-01 DOI:10.2147/IBPC.S360584
Thanh Xuan Nguyen, Van Tri Nguyen, Hong Ngoc Nguyen-Phan, Bui Bao Hoang
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引用次数: 3

Abstract

Objective This study aims to determine the serum levels of NT-proBNP in women with preeclampsia with and without severe signs and to evaluate the cardiovascular risks in these two groups of participants. Methods A descriptive cross-sectional study was conducted on 52 women with preeclampsia in the Department of Gynecology and Obstetrics – Hue Central Hospital, from August 2019 to September 2020. Results In preeclampsia women, the rate of hypertension in stage 3, stage 2, and stage 1 were 46.1%, 32.7%, and 21.2%, respectively. The average Sokolow-Lyon index in the preeclampsia group with and without severe signs was 22.25 ± 7.38mm, 20.16 ± 5.54mm, respectively. The average left ventricular mass index in the group of preeclampsia patients without and with severe signs was 92.27 ± 14.56g/m2 and 120.68 ± 16.47g/m2, respectively. The average ejection fraction in the group of preeclampsia patients without severe signs and with severe signs was 65.11 ± 3.45%, 56.21 ± 7.12%, correspondingly. In contrast, the difference between the two groups was statistically significant with p < 0.05. The plasma NT-proBNP level in the preeclampsia group without severe signs was 349.12 ± 93.51pg/mL, whereas the concentration in the preeclampsia group with severe signs was 725.32 ± 290.46pg/mL (p < 0.05). Conclusion The NT-proBNP level was statistically significantly increased in the patients with preeclampsia. Analyzing and comparing the figures and changes found in two groups of PE patients, with and without severe signs, we suggest that women diagnosed with PE with severe signs have a higher risk of developing cardiovascular problems forthwith and henceforth.
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子痫前期患者血清NT-Pro BNP水平的变化
目的本研究旨在测定先兆子痫伴和不伴严重症状妇女的血清NT-proBNP水平,并评估这两组参与者的心血管风险。方法2019年8月至2020年9月,对顺化市中心医院妇产科52名先兆子痫妇女进行描述性横断面研究。结果子痫前期妇女3期、2期和1期的高血压发生率分别为46.1%、32.7%和21.2%。先兆子痫伴和不伴严重体征组的平均Sokolow-Lyon指数分别为22.25±7.38mm和20.16±5.54mm。先兆子痫无症状组和有严重症状组的平均左心室质量指数分别为92.27±14.56g/m2和120.68±16.47g/m2。先兆子痫无严重体征组和有严重体征组的平均射血分数分别为65.11±3.45%、56.21±7.12%。相反,两组之间的差异具有统计学意义,p<0.05。无先兆子痫组血浆NT-proBNP水平为349.12±93.51pg/mL,有先兆子痫组为725.32±290.46pg/mL(p<0.05)。通过分析和比较两组PE患者(有严重体征和无严重体征)的数据和变化,我们认为,被诊断为PE伴严重体征的女性立即和以后出现心血管问题的风险更高。
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来源期刊
Integrated Blood Pressure Control
Integrated Blood Pressure Control PERIPHERAL VASCULAR DISEASE-
CiteScore
4.60
自引率
0.00%
发文量
13
审稿时长
16 weeks
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