Phytotherapeutics of Vicia faba L. in Parkinson’s Disease: An in silico Approach

Abstract

Vicia faba L. has a major role in the traditional diet and medicinal system of different countries. V. faba is a natural source of the precursor of dopamine (Levodopa) which is used treatment of Parkinson’s disease. The objective of the study is to investigate the in vitro antioxidant capacity, Gas Chromatography-Mass Spectrometry and docking of V. faba against Parkinson’s disease. The values indicated that acetone and aqueous extract exhibited a higher value of total phenolic and flavonoid contents respectively. The results of the 2, 2- diphenyl-1- picrylhydrazyl free radical scavenging assay and ferric reducing antioxidant power assay displayed that aqueous extract had better radical scavenging activity. In the 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonate) radical scavenging assay, ethanolic extract showed a lower Inhibitory Concentration50 value. In silico analysis indicated that the phyto-compounds present in V. faba has a higher binding affinity to the dopamine1 receptor. The results suggested that V. faba has good antioxidant properties and can be used as a dopamine agonist for the dopamine1 receptor which may be useful in combating Parkinson’s disease.