The author reports a rare case of multiple organ primary extranodal lymphoma, male, 63 years old. CT examination revealed multiple nodules or masses in multiple organs (lung, pericardium, pancreas, gallbladder, spine) of the chest and abdomen. The shape, density, and signal of the lesions were similar on CT and MRI, and the imaging manifestations had obvious characteristics. The final pathological diagnosis was lymphoma, and after treatment, it improved significantly.