{"title":"Effectiveness of Pyridostigmine and Pyridoxine in Vinca AlkaloidInduced Cranial Neuropathy – A Case Series","authors":"Aparajita Gupta, Shuvendu Roy, Prateep Paul","doi":"10.3126/jnps.v42i2.42865","DOIUrl":null,"url":null,"abstract":"The neurotoxicity of the vinca alkaloids in the form of peripheral neuropathy is well known, however, cranial neuropathy is not widely recognized especially in children. We describe here in three children with malignancies who developed vinca alkaloid induced cranial nerve palsies during treatment which resolved on institution of pyridoxine and pyridostigmine. Vinca-alkaloid-induced cranial nerve palsies represent a potentially dangerous but reversible condition.","PeriodicalId":39140,"journal":{"name":"Journal of Nepal Paediatric Society","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nepal Paediatric Society","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3126/jnps.v42i2.42865","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
The neurotoxicity of the vinca alkaloids in the form of peripheral neuropathy is well known, however, cranial neuropathy is not widely recognized especially in children. We describe here in three children with malignancies who developed vinca alkaloid induced cranial nerve palsies during treatment which resolved on institution of pyridoxine and pyridostigmine. Vinca-alkaloid-induced cranial nerve palsies represent a potentially dangerous but reversible condition.
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