Neuroprotective Effects of Cerebroprotein Hydrolysate on MPTP-induced Parkinson's Mice by Increasing Neurotrophin and Regulating Intestinal Microbiota

Abstract

It is hypothesized that the neurotrophin loss and the intestinal tract could be a contributing factor to the neurodegenerative processes. Cerebroprotein hydrolysate-I (CH-I), a mixture of amino acids and low molecular peptides had been reported to show remarkable therapeutic effect on many neurological diseases. However, the reports about the effects of cerebroprotein hydrolysate on PD was little. In this study, we applied CH-I on MPTP-induced mice to detect the neuroprotective effects. The results showed that CH-I could enhance the expression of neurotrophin (NGF and BDNF) and improve the behavioral deficits in MPTP-induced Parkinson's mice. Furthermore, CH-I restored the level of tyrosine hydroxylase (TH), and inhibited the apoptosis induced by MPTP. In addition, CH-I made a contribution to reducing the abundance of pathogenic microbiota and increasing the relative abundance of beneficial bacteria. The data demonstrate that CH-I shows promise as a novel treatment of PD.