Carbonate-Hydroxyapatite Cement: The Effect of Composition on Solubility In Vitro and Resorption In Vivo

IF 2.7 Q1 MATERIALS SCIENCE, CERAMICS Ceramics-Switzerland Pub Date : 2023-07-03 DOI:10.3390/ceramics6030086

Yu. S. Lukina, L. Bionyshev-Abramov, S. Kotov, Natalya Serejnikova, D. Smolentsev, S. Sivkov

{"title":"Carbonate-Hydroxyapatite Cement: The Effect of Composition on Solubility In Vitro and Resorption In Vivo","authors":"Yu. S. Lukina, L. Bionyshev-Abramov, S. Kotov, Natalya Serejnikova, D. Smolentsev, S. Sivkov","doi":"10.3390/ceramics6030086","DOIUrl":null,"url":null,"abstract":"The rate of resorption of calcium phosphate self-hardening materials for bone regeneration can be changed by changing the phase composition. The Ca3(PO4)2/CaCO3/Ca(H2PO4)2·H2O/Na2HPO4·12H2O system is important for the synthesis of self-curing bioactive materials with variable resorption rates by changing the ratios of the initial components. Cement compositions in twelve figurative points of a four-component composition diagram at a fixed content in the α-Ca3(PO4)2 system were studied with XRD, FTIR, SEM, calorimetric, and volumetric methods to obtain an idea of the effect of composition on solubility in vitro and resorption in vivo. It was found that the presence of the highly resorbable phase of dicalcium phosphate dihydrate in cement and the substitution of phosphate ions with the carbonate ions of hydroxyapatite increased solubility in vitro and resorption in vivo. The obtained results confirm the possibility of changing the solubility of a final product in the Ca3(PO4)2/CaCO3/Ca(H2PO4)2·H2O/Na2HPO4·12H2O system by changing the ratio of the initial components.","PeriodicalId":33263,"journal":{"name":"Ceramics-Switzerland","volume":" ","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ceramics-Switzerland","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/ceramics6030086","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, CERAMICS","Score":null,"Total":0}

引用次数: 2

Abstract

The rate of resorption of calcium phosphate self-hardening materials for bone regeneration can be changed by changing the phase composition. The Ca3(PO4)2/CaCO3/Ca(H2PO4)2·H2O/Na2HPO4·12H2O system is important for the synthesis of self-curing bioactive materials with variable resorption rates by changing the ratios of the initial components. Cement compositions in twelve figurative points of a four-component composition diagram at a fixed content in the α-Ca3(PO4)2 system were studied with XRD, FTIR, SEM, calorimetric, and volumetric methods to obtain an idea of the effect of composition on solubility in vitro and resorption in vivo. It was found that the presence of the highly resorbable phase of dicalcium phosphate dihydrate in cement and the substitution of phosphate ions with the carbonate ions of hydroxyapatite increased solubility in vitro and resorption in vivo. The obtained results confirm the possibility of changing the solubility of a final product in the Ca3(PO4)2/CaCO3/Ca(H2PO4)2·H2O/Na2HPO4·12H2O system by changing the ratio of the initial components.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

碳酸盐羟基磷灰石水泥：组成对体外溶解度和体内吸收的影响

磷酸钙自硬化材料的骨再生吸收速率可以通过改变相组成来改变。Ca3(PO4)2/CaCO3/Ca(H2PO4)2·H2O/Na2HPO4·12H2O体系是通过改变初始组分的比例来合成具有可变吸收率的自固化生物活性材料的重要体系。采用XRD、FTIR、SEM、量热法和体积法研究了固定含量α-Ca3(PO4)2体系中水泥四组分组成图中12个点上的水泥组分，以了解水泥组分对其体外溶解度和体内吸收的影响。研究发现，在水泥中存在高度可吸收的二水磷酸二钙相，以及磷酸盐离子被羟基磷灰石的碳酸盐离子取代，增加了水泥在体外的溶解度和体内的吸收。所得结果证实了通过改变初始组分的比例，可以改变Ca3(PO4)2/CaCO3/Ca(H2PO4)2·H2O/Na2HPO4·12H2O体系中最终产物的溶解度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊