Biodegradable polymer hydrogel-based tissue adhesives: A review

IF 1.6 Q4 ENGINEERING, BIOMEDICAL Biosurface and Biotribology Pub Date : 2021-08-03 DOI:10.1049/bsb2.12016

Xin Zhang, Yanan Jiang, Lu Han, Xiong Lu

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引用次数: 12

Abstract

Tissue-adhesive materials are emerging biomaterials with potential applications in wound healing patches, tissue sealants, and haemostat materials. Tissue adhesives based on synthetic polymers generally have good adhesion but are not biodegradable. However, the long-term presence of non-biodegradable adhesives in the body can cause secondary harm to the patient. An ideal tissue adhesive should meet the following requirements: good adhesiveness, biodegradability, low cytotoxicity, and minimal inflammatory response. Natural polymers with inherent biodegradation and biocompatibility show great potentials in biomedical engineering, and the development of tissue adhesives based on natural polymers has become a hot topic in biomaterials science. This review systematically summarises the latest progresses in biodegradable tissue adhesives based on natural polymers, such as chitosan, hyaluronic acid, alginate, gelatin, dextran, and cellulose. Methods for preparing natural polymer tissue adhesives are summarised and their advantages and disadvantages are discussed. Finally, potential trends in the future direction of biodegradable tissue adhesives are discussed.

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可生物降解聚合物水凝胶基组织粘接剂的研究进展

组织粘接材料是一种新兴的生物材料，在伤口愈合贴片、组织密封剂和止血材料方面具有潜在的应用前景。基于合成聚合物的组织胶粘剂通常具有良好的附着力，但不能生物降解。然而，不可生物降解的粘合剂在体内的长期存在会对患者造成二次伤害。理想的组织胶粘剂应满足以下要求:良好的黏附性、生物降解性、低细胞毒性和最小的炎症反应。具有生物降解和生物相容性的天然聚合物在生物医学工程中显示出巨大的潜力，基于天然聚合物的组织粘接剂的开发已成为生物材料科学研究的热点。本文系统地综述了以壳聚糖、透明质酸、海藻酸盐、明胶、葡聚糖和纤维素等天然聚合物为基础的可生物降解组织胶粘剂的最新研究进展。综述了天然高分子组织粘接剂的制备方法，并对其优缺点进行了讨论。最后，对生物可降解组织胶粘剂的发展趋势进行了展望。

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