{"title":"Epigenome editing in mice: The dawn of the reverse epigenetics era","authors":"Izuho Hatada , Sumiyo Morita , Takuro Horii","doi":"10.1016/j.ggedit.2022.100012","DOIUrl":null,"url":null,"abstract":"<div><p>Epigenome editing is a technique by which the epigenome of a specific DNA may be manipulated. The application of this technology to mouse zygotes or mouse embryonic stem cells (mESC) to produce mice with modified epigenomes would allow determination of the phenotypic role of the epigenome of a specific region for a given gene. In other words, reverse epigenetics becomes possible. In this review, we will discuss the significance of epigenome editing, the methods available, and the application of epigenome editing in mice.</p></div>","PeriodicalId":73137,"journal":{"name":"Gene and genome editing","volume":"3 ","pages":"Article 100012"},"PeriodicalIF":0.0000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666388022000028/pdfft?md5=c829c327b72642f48d34229500855fb2&pid=1-s2.0-S2666388022000028-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gene and genome editing","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666388022000028","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Epigenome editing is a technique by which the epigenome of a specific DNA may be manipulated. The application of this technology to mouse zygotes or mouse embryonic stem cells (mESC) to produce mice with modified epigenomes would allow determination of the phenotypic role of the epigenome of a specific region for a given gene. In other words, reverse epigenetics becomes possible. In this review, we will discuss the significance of epigenome editing, the methods available, and the application of epigenome editing in mice.
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