Impact of diabetic peripheral neuropathy on gait abnormalities in patients with type 2 diabetes mellitus.

IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM Diabetology International Pub Date : 2023-08-16 eCollection Date: 2024-01-01 DOI:10.1007/s13340-023-00652-y
Samir H Assaad Khalil, Hany Mohammed Ali El Deeb, Martin Otwang Dak Ajang, Nermin A Osman, Noha Gaber Amin
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Abstract

Background: Many patients with type 2 diabetes (T2DM) suffer from diabetic peripheral neuropathy (DPN) and impaired muscle coordination. These changes may lead to walking instability, and gait abnormalities resulting in increased fall risk and lower limb amputations. The aim of this study was to assess the impact of DPN and patient footwear on the gait in patients with diabetes, in addition to Comparing the peak plantar pressure (PPP) in patients with and without DPN and assessing its association with gait abnormalities.

Methodology: This is an observational case-control study. Forty Subjects with T2DM were divided into two age and sex-matched groups, 20 subjects each. Group A: subjects with DPN. Group B: subjects without DPN. All study participants were subjected to a thorough history taking, clinical examinations focusing on detailed foot examination, PPP assessment, and functional gait evaluation.

Results: The results obtained in this study showed a median gait assessment score of 21 (17.0-22.5) for group A and 26 (23.5-26.0) for group B which was statistically significant (p < 0.001). There was no statistically significant difference between both groups (p > 0.05) regarding the assessment of footwear appropriateness. Comparing the PPP measurement among both studied groups, the prevalence of an elevated PPP was 80% in group A compared to 65% in group B, which was statistically non-significant, p = 0.288.

Conclusions: Gait abnormalities are common among patients with T2DM even in the absence of DPN. However, the presence of DPN was the strongest independent risk factor for gait abnormalities among the studied factors.

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糖尿病周围神经病变对2型糖尿病患者步态异常的影响
背景:许多 2 型糖尿病(T2DM)患者患有糖尿病周围神经病变(DPN),肌肉协调能力受损。这些变化可能导致行走不稳和步态异常,从而增加跌倒和下肢截肢的风险。本研究旨在评估 DPN 和患者鞋袜对糖尿病患者步态的影响,同时比较有 DPN 和无 DPN 患者的足底压力峰值(PPP),并评估其与步态异常的关联:这是一项观察性病例对照研究。40 名 T2DM 受试者被分为年龄和性别匹配的两组,每组 20 人。A组:患有DPN的受试者。B 组:无 DPN 的受试者。所有研究对象均接受了全面的病史采集、临床检查,重点是详细的足部检查、PPP 评估和功能步态评估:研究结果显示,A 组的步态评估得分中位数为 21(17.0-22.5)分,B 组为 26(23.5-26.0)分。比较两个研究组的 PPP 测量结果,A 组的 PPP 升高率为 80%,B 组为 65%,差异无统计学意义(P = 0.288):即使没有 DPN,步态异常在 T2DM 患者中也很常见。然而,在所有研究因素中,DPN的存在是导致步态异常的最强独立风险因素。
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来源期刊
Diabetology International
Diabetology International ENDOCRINOLOGY & METABOLISM-
CiteScore
3.90
自引率
4.50%
发文量
42
期刊介绍: Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.
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