{"title":"Thermal Decomposition Kinetics of Ursodeoxycholic Acid Drug Crystal","authors":"S. Ramukutty, R. Jeyasudha, E. Ramachandran","doi":"10.4236/JCPT.2017.74006","DOIUrl":null,"url":null,"abstract":"The crystallization of ursodeoxycholic acid drug crystals in gel by reduction of solubility method is the first of its kind to be reported in literature. Monoclinic crystalline form of the structure was confirmed using single crystal X-ray diffraction analysis. This report deals with the kinetic analysis made from the thermogravimetric analysis/differential thermal analysis (TGA/DTA) data using Coats-Redfern (CR) relation. Thermodynamic parameters were also determined. Arrhenius equation for ursodeoxycholic acid was derived as k = 3.10 × 1010 e−172581/RT mol−1•s−1.","PeriodicalId":64440,"journal":{"name":"结晶过程及技术期刊(英文)","volume":"07 1","pages":"85-90"},"PeriodicalIF":0.0000,"publicationDate":"2017-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"结晶过程及技术期刊(英文)","FirstCategoryId":"1087","ListUrlMain":"https://doi.org/10.4236/JCPT.2017.74006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The crystallization of ursodeoxycholic acid drug crystals in gel by reduction of solubility method is the first of its kind to be reported in literature. Monoclinic crystalline form of the structure was confirmed using single crystal X-ray diffraction analysis. This report deals with the kinetic analysis made from the thermogravimetric analysis/differential thermal analysis (TGA/DTA) data using Coats-Redfern (CR) relation. Thermodynamic parameters were also determined. Arrhenius equation for ursodeoxycholic acid was derived as k = 3.10 × 1010 e−172581/RT mol−1•s−1.
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