Mitochondrial biogenesis alteration in arsenic-induced carcinogenesis and its therapeutic interventions

IF 3.3 4区医学 Q2 TOXICOLOGY Toxin Reviews Pub Date : 2022-10-03 DOI:10.1080/15569543.2022.2124420

K. Sathua, R. Singh

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Abstract

Abstract Arsenic poisoning is one of the major devastation and horrific concerns across the globe. Its concentration in the environment is continuously increasing over time, and hence it may play a role of exterminator for the future civilization. Cancer is the one of the main detrimental outcomes of arsenic poisoning. The International Agency for Research on Cancer suggested arsenic as a class-1 carcinogen. The underlying mechanism pertaining to arsenic-induced carcinogenesis is still enigmatic. Although plentiful evidences have vouched that the redox machinery is the main culprit for arsenic-induced carcinogenesis, however several reports have documented regarding participation of mitochondria as the root originators of the redox signaling in arsenic-induced carcinogenesis. Moreover, the redox machinery system plays a vital role in regulating mitochondrial biogenesis and homeostasis. However, there is still a knowledge gap regarding the influence of redox machinery systems on mitochondrial biogenesis and homeostasis in the development of arsenic-induced carcinogenesis. The objectives of this paper are to review and evaluate the role of mitochondrial biogenesis in the development of arsenic-induced carcinogenesis in addition to the possible therapeutic option for modulation of such signaling mechanisms.

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砷致癌过程中线粒体生物发生改变及其治疗干预

砷中毒是全球范围内的主要破坏和可怕问题之一。随着时间的推移，它在环境中的浓度不断增加，因此它可能在未来的文明中扮演灭虫者的角色。癌症是砷中毒的主要有害后果之一。国际癌症研究机构将砷列为一级致癌物。与砷诱发的癌变有关的潜在机制仍然是个谜。尽管大量证据证明氧化还原机制是砷诱导癌变的罪魁祸首，但也有一些报道证明线粒体作为氧化还原信号在砷诱导癌变中的根本发起者参与。此外，氧化还原机制系统在调节线粒体生物发生和体内平衡中起着至关重要的作用。然而，关于氧化还原机制系统对砷诱导癌变过程中线粒体生物发生和稳态的影响，目前仍存在知识空白。本文的目的是回顾和评估线粒体生物发生在砷诱导癌变的发展中的作用，以及调节这种信号机制的可能的治疗选择。

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来源期刊

Toxin Reviews 医学-毒理学

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Toxin Reviews provides an international forum for publishing state-of-the-art reviews and guest-edited single topic special issues covering the multidisciplinary research in the area of toxins derived from animals, plants and microorganisms. Our aim is to publish reviews that are of broad interest and importance to the toxinology as well as other life science communities. Toxin Reviews aims to encourage scientists to highlight the contribution of toxins as research tools in deciphering molecular and cellular mechanisms, and as prototypes of therapeutic agents. Reviews should emphasize the role of toxins in enhancing our fundamental understanding of life sciences, protein chemistry, structural biology, pharmacology, clinical toxinology and evolution. Prominence will be given to reviews that propose new ideas or approaches and further the knowledge of toxinology.