{"title":"The Relationship of Secretion and Activity of Recombinant Factor IX with N-Glycosylation","authors":"S. Khalilzadeh, J. Vatandoost","doi":"10.32598/RMM.8.1.31","DOIUrl":null,"url":null,"abstract":"Background: Human coagulation factor IX (hFIX) is a glycoprotein with two N-glycosylation sites at the activation peptide. Since the activation peptide is removed in mature hFIX, the exact role of N-glycosylation is unclear. To investigate the role of N-glycosylation in the secretion and activity of hFIX, we inhibited N-glycosylation by tunicamycin in the stable Human Embryonic Kidney (HEK)coagulation Factor IX (FIX) cells.","PeriodicalId":30778,"journal":{"name":"Research in Molecular Medicine","volume":"8 1","pages":"31-36"},"PeriodicalIF":0.0000,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research in Molecular Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32598/RMM.8.1.31","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Human coagulation factor IX (hFIX) is a glycoprotein with two N-glycosylation sites at the activation peptide. Since the activation peptide is removed in mature hFIX, the exact role of N-glycosylation is unclear. To investigate the role of N-glycosylation in the secretion and activity of hFIX, we inhibited N-glycosylation by tunicamycin in the stable Human Embryonic Kidney (HEK)coagulation Factor IX (FIX) cells.
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