{"title":"Genotoxicity of engineered nanomaterials found in the human environment","authors":"A. Wallace Hayes , Saura C. Sahu","doi":"10.1016/j.cotox.2019.12.003","DOIUrl":null,"url":null,"abstract":"<div><p>Engineered nanomaterials<span><span> (ENMs) are unique in our modern industrial world; however, limited information is currently available regarding exposure and hazard information, including the genotoxicity of such materials. Much work remains to be carried out for developing, validating, and harmonizing a tool chest for the genotoxicity of nanomaterials. Gaps remain in our understanding of potential mechanisms of the genotoxicity of nanomaterials. Until more appropriate tests are available for testing of ENMs, the potential impact of ENMs may continue to be underestimated without proper consideration of the genotoxicity potential of such materials. Clearly, resources need to be devoted to better approaches to the </span>hazard identification of nanomaterials to insure safe development and application of nanotechnology and for the protection of human health and the environment.</span></p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"19 ","pages":"Pages 68-71"},"PeriodicalIF":3.6000,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2019.12.003","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S246820201930107X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/12/23 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 7
Abstract
Engineered nanomaterials (ENMs) are unique in our modern industrial world; however, limited information is currently available regarding exposure and hazard information, including the genotoxicity of such materials. Much work remains to be carried out for developing, validating, and harmonizing a tool chest for the genotoxicity of nanomaterials. Gaps remain in our understanding of potential mechanisms of the genotoxicity of nanomaterials. Until more appropriate tests are available for testing of ENMs, the potential impact of ENMs may continue to be underestimated without proper consideration of the genotoxicity potential of such materials. Clearly, resources need to be devoted to better approaches to the hazard identification of nanomaterials to insure safe development and application of nanotechnology and for the protection of human health and the environment.
期刊介绍：
The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.
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