Genotoxicity of engineered nanomaterials found in the human environment

Abstract

Engineered nanomaterials (ENMs) are unique in our modern industrial world; however, limited information is currently available regarding exposure and hazard information, including the genotoxicity of such materials. Much work remains to be carried out for developing, validating, and harmonizing a tool chest for the genotoxicity of nanomaterials. Gaps remain in our understanding of potential mechanisms of the genotoxicity of nanomaterials. Until more appropriate tests are available for testing of ENMs, the potential impact of ENMs may continue to be underestimated without proper consideration of the genotoxicity potential of such materials. Clearly, resources need to be devoted to better approaches to the hazard identification of nanomaterials to insure safe development and application of nanotechnology and for the protection of human health and the environment.