Natural Viruses of Caenorhabditis Nematodes.

IF 8.7 1区生物学 Q1 GENETICS & HEREDITY Annual review of genetics Pub Date : 2019-12-03 DOI:10.1146/annurev-genet-112618-043756

M. Félix, David Wang

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引用次数: 22

Abstract

Caenorhabditis elegans has long been a laboratory model organism with no known natural pathogens. In the past ten years, however, natural viruses have been isolated from wild-caught C. elegans (Orsay virus) and its relative Caenorhabditis briggsae (Santeuil virus, Le Blanc virus, and Melnik virus). All are RNA positive-sense viruses related to Nodaviridae; they infect intestinal cells and are horizontally transmitted. The Orsay virus capsid structure has been determined and the virus can be reconstituted by transgenesis of the host. Recent use of the Orsay virus has enabled researchers to identify evolutionarily conserved proviral and antiviral genes that function in nematodes and mammals. These pathways include endocytosis through SID-3 and WASP; a uridylyltransferase that destabilizes viral RNAs by uridylation of their 3' end; ubiquitin protein modifications and turnover; and the RNA interference pathway, which recognizes and degrades viral RNA. Expected final online publication date for the Annual Review of Genetics, Volume 53 is November 23, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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线虫的天然病毒。

秀丽隐杆线虫长期以来一直是一种实验室模式生物，没有已知的天然病原体。然而，在过去的十年中，从野生秀丽隐杆线虫（Orsay病毒）及其亲缘的亮杆线虫（Santeuil病毒、勒布朗克病毒和Melnik病毒）中分离出了天然病毒。均为与结节病毒科相关的RNA阳性病毒；它们感染肠道细胞并水平传播。奥赛病毒衣壳结构已经确定，病毒可以通过宿主的转基因重组。最近奥赛病毒的使用使研究人员能够识别进化上保守的前病毒和抗病毒基因，这些基因在线虫和哺乳动物中发挥作用。这些途径包括通过SID-3和WASP的内吞作用；尿苷基转移酶，通过病毒RNA 3’端的尿苷基化使其不稳定；泛素蛋白修饰和周转；以及识别和降解病毒RNA的RNA干扰途径。《遗传学年度评论》第53卷预计最终在线出版日期为2019年11月23日。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual review of genetics 生物-遗传学

CiteScore

18.30

自引率

0.90%

发文量

期刊介绍： The Annual Review of Genetics, published since 1967, comprehensively covers significant advancements in genetics. It encompasses various areas such as biochemical, behavioral, cell, and developmental genetics, evolutionary and population genetics, chromosome structure and transmission, gene function and expression, mutation and repair, genomics, immunogenetics, and other topics related to the genetics of viruses, bacteria, fungi, plants, animals, and humans.

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