Applications of Different Biomarkers in the Diagnosis of Drug-induced Liver Injury

Q3 Medicine Open Biomarkers Journal Pub Date : 2019-09-30 DOI:10.2174/1875318301909010055

Monika Sharma, Ishita Yadav, C. Sharma

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Abstract

Biomarkers perform a significant function in the process of drug development. Biomarkers have been utilized in the safety assessment of drugs in clinical practice and also for personalization of medicines. To recognize the relation among considerable biological processes as well as clinical outcomes, it is important to increase our potential of treatments for all ailments, in addition to our understanding of normal and healthy physiology. Since the 1980s, using biomarkers is essential for substitutional results in long term assessments of main maladies, for example, cancer, as well as illness related to the heart. Now a days, biomarkers are highly important for unifying discovery of the drug and day by day improvements. The importance of biomarkers is increasing gradually with the advancement of novel therapeutics for the treatment and prevention of a broad range of diseases in order to overcome hepatotoxicity. These biomarkers are extensively used for the identification of disease and the field of medical research. The use of biomarkers in clinical as well as basic research has been promoted rapidly by the different drug regulation authorities for better outcomes in the future.

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不同生物标志物在药物性肝损伤诊断中的应用

生物标志物在药物开发过程中发挥着重要的作用。生物标志物已在临床实践中用于药物的安全性评估，也用于药物的个性化。为了认识到相当多的生物过程和临床结果之间的关系，除了我们对正常和健康生理学的理解之外，增加我们对所有疾病的治疗潜力是很重要的。自20世纪80年代以来，使用生物标志物对于主要疾病(例如癌症以及与心脏有关的疾病)的长期评估的替代结果至关重要。如今，生物标志物对于统一药物的发现和一天天的改进是非常重要的。随着新疗法的发展，生物标志物的重要性逐渐增加，用于治疗和预防各种疾病，以克服肝毒性。这些生物标记物被广泛用于疾病识别和医学研究领域。生物标志物在临床和基础研究中的应用已被不同的药物监管机构迅速推动，以获得更好的未来结果。

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来源期刊

Open Biomarkers Journal Medicine-Medicine (miscellaneous)

CiteScore

0.80

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0.00%

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期刊介绍： The Open Biomarkers Journal is an Open Access online journal, which publishes original full-length, short research articles and reviews on biomarkers in clinical, medical and pharmaceutical research. The coverage includes biomarkers of disease, new biomarkers, exposure to drugs, genetic effects, and applications of biomarkers. The Open Biomarkers Journal, a peer reviewed journal, aims to provide the most complete and reliable source of information on current developments in the field. The emphasis will be on publishing quality articles rapidly and freely available to researchers worldwide.