Unusual phenotype of acute motor sensory axonal neuropathy with ophthalmoplegia, and anti-GD1a, -GD1b and -GM1 antibodies

Pub Date : 2022-04-30 DOI:10.1111/cen3.12704

Theodora Afrantou, Vasilios Kimiskidis, Roza Lagoudaki, Thomai Stardeli, Vasileios Papaliagkas, Georgia Zafeiridou, Giannoula Thoma, Zoi Aidoni, Nikolaos Grigoriadis

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Abstract

Background

Acute motor sensory axonal neuropathy (AMSAN) is a severe form of Guillain–Barré syndrome, which typically is not related to ocular palsy, and is pathologically associated with antibodies against GM1 and GD1a gangliosides.

Case presentation

We present a patient with a severe, drug-resistant form of AMSAN with ophthalmoplegia related to antiganglioside (anti-GD1a, -GD1b, -GM1) antibodies in the serum and cerebrospinal fluid, and with a poor long-term outcome.

Conclusions

Rare cases of AMSAN with ophthalmoplegia are described in the literature. The present patient is a case of an unusual clinical phenotype of AMSAN, the characteristics of which warn of a serious clinical course that requires timely aggressive treatment.

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急性运动感觉轴索神经病伴眼麻痹的异常表型，以及抗- GD1a， - GD1b和- GM1抗体

急性运动感觉轴索神经病变(AMSAN)是吉兰-巴罗综合征的一种严重形式，通常与眼性麻痹无关，并且在病理上与针对GM1和GD1a神经节苷脂的抗体相关。

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