Synchronous serous carcinoma arising in adenomyosis and small cell carcinoma of ovary - pulmonary type (SCOOPT): a case report and literature review

Abstract

Background: Serous carcinoma arising in adenomyosis is rare, only 8 cases have been reported in the literature. Primary small cell carcinoma of ovary - pulmonary type (SCOOPT) is a rare, aggressive entity associated with poor outcomes and limited treatment options. The two malignant tumors synchronously happen at one patient has never been reported before.Case presentation: We summarized and analyzed the clinicopathological features of 1 serous carcinoma arising in adenomyosis synchronous with SCOOPT and reviewed the literature. A 60-year-old postmenopausal woman presented to our hospital with abdominal distension, abdominal pain, and constipation. Colonoscopy and computed tomography (CT) scan of pulmonary showed no abnormalities. Ultrasonography and CT scan revealed a solid-cystic mass in the pelvic cavity, slightly thickened uterine myometrium at the fundus with heterogeneous echo. A total abdominal hysterectomy, bilateral salpingo-oophorectomy, and pelvic and para-aortic lymphadenectomy were performed. The final pathology showed serous carcinoma originating from adenomyosis, while the eutopic endometrium and both fallopian epithelia were identified with no cancer. The solid-cystic mass in the right ovary is diagnosed with SCCOPT and metastasis to the myometrium of the uterus. The prognosis of previously reported cancers of adenomyosis origin and SCOOPT were both poor, while our case was alive without disease during the 6-month follow-up.Conclusion: We believe this case report will expand our recognition of the coexistence of serous carcinoma arising in adenomyosis with small cell carcinoma of the ovary–pulmonary type (SCOOPT).