{"title":"A single antiviral for a triple epidemic: is it possible?","authors":"N. Sultanoglu, E. Erdag, Cenk Serhan Ozverel","doi":"10.2217/fvl-2023-0048","DOIUrl":null,"url":null,"abstract":"Aim: A triple epidemic of respiratory syncytial virus (RSV), SARS-CoV-2 and influenza variants is on the rise worldwide. It is crucial to identify antiviral agents that can be used against all three viruses associatd with this triple epidemic. Materials & methods: A total of ten antiviral agents were investigated in this study. Using molecular docking and the molecular mechanics/position-Boltzmann surface area technique, an examination of the binding affinity and protein–ligand interactions was conducted. Results: Out of the ten ligands that were compared, three showed the highest affinity for the docking site related to three the viral infections in descending order: AVG-388, remdesivir and nirmatrelvir. Conclusion: In conclusion, AVG-388, remdesivir and nirmatrelvir could be recommended as effective antiviral agents during the triple epidemic.","PeriodicalId":12505,"journal":{"name":"Future Virology","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2023-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future Virology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2217/fvl-2023-0048","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VIROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Aim: A triple epidemic of respiratory syncytial virus (RSV), SARS-CoV-2 and influenza variants is on the rise worldwide. It is crucial to identify antiviral agents that can be used against all three viruses associatd with this triple epidemic. Materials & methods: A total of ten antiviral agents were investigated in this study. Using molecular docking and the molecular mechanics/position-Boltzmann surface area technique, an examination of the binding affinity and protein–ligand interactions was conducted. Results: Out of the ten ligands that were compared, three showed the highest affinity for the docking site related to three the viral infections in descending order: AVG-388, remdesivir and nirmatrelvir. Conclusion: In conclusion, AVG-388, remdesivir and nirmatrelvir could be recommended as effective antiviral agents during the triple epidemic.
期刊介绍：
Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.
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