Antibacterial Drug Releasing Materials by Post-Polymerization Surface Modification

IF 2.4 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Journal of Molecular and Engineering Materials Pub Date : 2017-07-27 DOI:10.1142/S2251237317400056
Shuyun Chng, M. Moloney, L. Wu
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引用次数: 2

Abstract

Functional materials are available by the post-polymerization surface modification of diverse polymers in a three-step process mediated, firstly, by carbene insertion chemistry, secondly, by diazonium coupling, and thirdly by modification with a remotely tethered spiropyran unit, and these materials may be used for the reversible binding and release of Penicillin V. Surface loading densities of up to 0.19mmol/g polymer are achievable, leading to materials with higher loading densities and release behavior relative to unmodified controls, and observable antibacterial biocidal activity.
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聚合后表面改性的抗菌药物释放材料
功能材料可通过三步过程对不同聚合物进行聚合后表面改性获得,首先通过卡宾插入化学,其次通过重氮偶联,第三通过用远程连接的螺吡喃单元进行改性,这些材料可用于青霉素V的可逆结合和释放。可实现高达0.19mmol/g聚合物的表面负载密度,从而使材料相对于未改性的对照具有更高的负载密度和释放行为,并具有可观察到的抗菌杀生物活性。
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来源期刊
Journal of Molecular and Engineering Materials
Journal of Molecular and Engineering Materials MATERIALS SCIENCE, MULTIDISCIPLINARY-
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