{"title":"Antibacterial Drug Releasing Materials by Post-Polymerization Surface Modification","authors":"Shuyun Chng, M. Moloney, L. Wu","doi":"10.1142/S2251237317400056","DOIUrl":null,"url":null,"abstract":"Functional materials are available by the post-polymerization surface modification of diverse polymers in a three-step process mediated, firstly, by carbene insertion chemistry, secondly, by diazonium coupling, and thirdly by modification with a remotely tethered spiropyran unit, and these materials may be used for the reversible binding and release of Penicillin V. Surface loading densities of up to 0.19mmol/g polymer are achievable, leading to materials with higher loading densities and release behavior relative to unmodified controls, and observable antibacterial biocidal activity.","PeriodicalId":16406,"journal":{"name":"Journal of Molecular and Engineering Materials","volume":"05 1","pages":"1740005"},"PeriodicalIF":2.4000,"publicationDate":"2017-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S2251237317400056","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Molecular and Engineering Materials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1142/S2251237317400056","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 2
Abstract
Functional materials are available by the post-polymerization surface modification of diverse polymers in a three-step process mediated, firstly, by carbene insertion chemistry, secondly, by diazonium coupling, and thirdly by modification with a remotely tethered spiropyran unit, and these materials may be used for the reversible binding and release of Penicillin V. Surface loading densities of up to 0.19mmol/g polymer are achievable, leading to materials with higher loading densities and release behavior relative to unmodified controls, and observable antibacterial biocidal activity.