Effect of formaldehyde-based additive against African swine fever virus in complete swine feed

IF 0.3 Q4 AGRICULTURE, DAIRY & ANIMAL SCIENCE Journal of the Indonesian Tropical Animal Agriculture Pub Date : 2021-11-22 DOI:10.14710/jitaa.47.3.244-252

V. Ly, T. Hoang, A. Dang, S. Aupanun, C. Wongpukdee

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Abstract

African swine fever (ASF) is currently considered the serious contagious disease of the swine in-dustry worldwide. The feed and feed ingredients have been recognized as a potential risk factor for Af-rican swine fever virus (ASFV) transmission. No commercial vaccines and effective drugs against ASFV are available to date. This study aimed to examine the antimicrobial SALTEC™ 512, a formal-dehyde-based additive, at an application rate of 1.0; 2.0; and 3.0 kg/t feed against ASFV in complete swine feed. The effect of SALTEC™ 512 was evaluated by a contaminated ASFV feed assay. Our study reveals that SALTEC™ 512 inactivated ASF/VN/Pig/Hue/1270 strain in complete swine feed at an inclusion rate of 1.0 kg/t feed on Day 1 post inoculation. The most effective action was noticed at an inclusion level of 3.0 kg/t feed on Day 7 post inoculation. The antiviral activity of SALTEC™ 512 against ASF/VN/Pig/Hue/1270 was dose and time-dependent. Overall, SALTEC™ 512 may be a po-tential additive to reduce the risk of ASFV transmission via feed contamination.

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在全猪饲料中添加甲醛对非洲猪瘟病毒的抑制作用

非洲猪瘟(African swine fever, ASF)是目前世界范围内公认的严重的猪传染性疾病。饲料和饲料成分已被认为是非洲猪瘟病毒(ASFV)传播的潜在危险因素。迄今为止，还没有针对非洲猪瘟的商业疫苗和有效药物。本研究旨在检测SALTEC™512，一种基于甲醛的添加剂，在1.0的应用速率下;2.0;3.0 kg/t饲料中抗ASFV。通过污染的ASFV饲料试验评估SALTEC™512的效果。我们的研究表明，在接种后第1天，以1.0 kg/t饲料的添加率，SALTEC™512灭活了ASF/VN/Pig/Hue/1270菌株。接种后第7天，添加水平为3.0 kg/t的饲料时效果最佳。SALTEC™512对ASF/VN/Pig/Hue/1270的抗病毒活性是剂量和时间依赖性的。总的来说，SALTEC™512可能是一种潜在的添加剂，可以降低通过饲料污染传播非洲猪瘟的风险。

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来源期刊

Journal of the Indonesian Tropical Animal Agriculture AGRICULTURE, DAIRY & ANIMAL SCIENCE-

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： Journal of the Indonesian Tropical Animal Agriculture (JITAA) is a double blind peer-reviewed publication devoted to disseminate all information contributing to the understanding and development of animal agriculture in the tropics by publication of original research papers. The journal covers all aspect relating to Animal Agriculture, including: -Animal breeding and genetics -Animal feeding and nutrition -Animal reproduction -Animal biotechnology -Animal physiology -Animal production and technology -Animal products technology -Animal management and economics -Animal products processing and animal by-products -Animal microbiology -Livestock farming systems -Other related topics in relation to animal science. The topics of research are not only on Indonesian tropical animal agriculture, but also on other tropical regions of the world.