V. Salukhov, M. Kharitonov, N. A. Varavin, Alisa S. Krasovskaya, Alexander A. Santakov
{"title":"Impact of stress on hemostasis: A review","authors":"V. Salukhov, M. Kharitonov, N. A. Varavin, Alisa S. Krasovskaya, Alexander A. Santakov","doi":"10.26442/20751753.2023.2.202183","DOIUrl":null,"url":null,"abstract":"The article presents an overview of current views of changes in the hemostasis system in response to stress. Stress-induced neurohormonal responses activate the clotting system and inhibit the fibrinolysis system, leading to hypercoagulation. An evolutionary interpretation of such responses is that hypercoagulation under stress protects a healthy body from excessive bleeding in case of trauma in fight-or-flight situations. Acute psychological stress can cause significant hemoconcentration and prothrombotic changes in the blood, which can have potentially harmful effects on the cardiovascular system.","PeriodicalId":10550,"journal":{"name":"Consilium Medicum","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Consilium Medicum","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26442/20751753.2023.2.202183","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
The article presents an overview of current views of changes in the hemostasis system in response to stress. Stress-induced neurohormonal responses activate the clotting system and inhibit the fibrinolysis system, leading to hypercoagulation. An evolutionary interpretation of such responses is that hypercoagulation under stress protects a healthy body from excessive bleeding in case of trauma in fight-or-flight situations. Acute psychological stress can cause significant hemoconcentration and prothrombotic changes in the blood, which can have potentially harmful effects on the cardiovascular system.
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