Investigation of the effects of metal oxide nanoparticle mixtures on Danio rerio and Xenopus laevis embryos

IF 1.3 4区环境科学与生态学 Q3 ECOLOGY Chemistry and Ecology Pub Date : 2023-01-02 DOI:10.1080/02757540.2022.2162893

N. Ozmen, Duygu Ozhan Turhan, Abbas Güngördü, Hatice Çağlar Yılmaz, M. Ozmen

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Abstract

ABSTRACT In this study, the toxic effects of single TiO2, ZnO and Fe2O3 nanoparticles (NPs) and their binary and ternary combinations on the embryonic development of Xenopus laevis and Danio rerio were evaluated. It was aimed to determine the median lethal concentrations, growth retardation and developmental malformation effects and the effects of mixed nanoparticle exposure to selected enzyme biomarkers resulting from the exposure of embryos to NPs. The results showed that ZnO NPs, which are the most toxic according to the highest lethality level, cause developmental delay and malformations. The Fe2O3 and TiO2 NPs caused growth retardation only in D. rerio embryos. It was determined that double and triple combinations of NPs did not cause significant lethality in both species. Biochemical markers showed that mixed NPs could lead to greater toxicity compared to single exposures. The results also revealed that TiO2 or Fe2O3 NPs caused an increase in toxicity when co-existing with ZnO NP due to additive effects. Overall, the results showed that D. rerio was more susceptible to NP exposure in terms of growth and mortality than X. laevis. However, studies that are more comprehensive are needed to better understand the toxicity mechanism of metal oxide NP mixtures.

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金属氧化物纳米粒子混合物对斑蝥和非洲爪蟾胚胎影响的研究

摘要本研究评估了TiO2、ZnO和Fe2O3纳米颗粒及其二元和三元组合对非洲爪蟾和斑蝥胚胎发育的毒性作用。其目的是确定中位致死浓度、生长迟缓和发育畸形的影响，以及混合纳米粒子暴露于胚胎暴露于纳米粒子所产生的选定酶生物标志物的影响。结果表明，ZnO纳米颗粒的毒性最高，可导致发育迟缓和畸形。Fe2O3和TiO2纳米颗粒仅在灰蝶胚胎中引起生长迟缓。已经确定，NP的双重和三重组合不会对这两个物种造成显著的致命性。生化标记显示，与单一暴露相比，混合NP可能导致更大的毒性。结果还表明，当TiO2或Fe2O3 NP与ZnO NP共存时，由于添加剂效应，其毒性增加。总的来说，研究结果表明，就生长和死亡率而言，灰蝶比灰蝶更容易受到NP暴露的影响。然而，需要更全面的研究来更好地了解金属氧化物NP混合物的毒性机制。

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来源期刊

Chemistry and Ecology 环境科学-环境科学

CiteScore

4.20

自引率

16.00%

发文量

审稿时长

3.7 months

期刊介绍： Chemistry and Ecology publishes original articles, short notes and occasional reviews on the relationship between chemistry and ecological processes. This journal reflects how chemical form and state, as well as other basic properties, are critical in their influence on biological systems and that understanding of the routes and dynamics of the transfer of materials through atmospheric, terrestrial and aquatic systems, and the associated effects, calls for an integrated treatment. Chemistry and Ecology will help promote the ecological assessment of a changing chemical environment and in the development of a better understanding of ecological functions.