Biomedical applications of nanoscale tools and nano-bio interface: A blueprint of physical, chemical, and biochemical cues of cell mechanotransduction machinery

Abstract

A dream to have control over the cell behavior by nanoscale tools and nano-bio interface to mimic remodeling of cell mechanotransduction machinery, is an updated approach and the latest theme of current research.[1] To achieve such a goal, the nanofabrication technique plays a key role in designing novel nanoscale tools capable of stimulating the natural extracellular matrix (ECM). These nano-bio tools can create a valuable nanoscale interface, and finally, these advanced tools control cell behavior. Structurally and compositionally, the cells are too complicated and well equipped with remarkable features. It has a lot of complexity in it. The initial hurdle is the natural composition of cells and the surroundings of the nanoscale. The cell is too complicated, and it is a difficult and tough task to determine the features of its areas. The emergence of nanoscale tools, which are capable of analyzing and performing by applying single-molecule with high precision is helping for boosting cellular events for enhancing biomedical claims.[2] These tools and biomedical methods consist of nanomaterials that can perform as nanodevices, expose the cellular environment and simulate the cell-matrix interface. These biomedical methods are now considered major outfits for further analysis. [3] To detect the surface patterning of the cells and concerned topographies of cellular environments, these nanoscale devices, and 3D microporous scaffolds derived from nanomaterials are the main equipment applied to exploit the hidden areas and undiscovered activities of the cell components.