Cooperative systems constructed using crystalline metal complexes of short flexible peptides

IF 1.7 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2022-06-08 DOI:10.1007/s10847-022-01145-2
Ryosuke Miyake
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引用次数: 1

Abstract

Biological systems display a range of sophisticated functions that cannot be performed by artificial systems, through intricate cooperative structural changes involving multiple functional units. The designability and structural flexibility of peptides are demonstrated by biological systems that display cooperative structural changes; these properties also make them well-suited for the formation of artificial systems that display such changes. The problem with the use of peptide frameworks is that long peptide residues, which are not suitable for gram-scale use, are required for the formation of stable ordered structures. However, if ordered structures containing peptides could be constructed by coordinating them to metal ions, peptides could be widely used to develop sophisticated functional materials. Crystal packing can be used for the design of functional materials made from simple molecules because it provides a way to place the components relative to each other. Although crystalline systems have been reported in which the small size of the cavities has been attributed to the flexibility of the peptide, recently, large systems with giant cavities have been developed with flexible peptides. In this review, we summarize the formation of cooperative multicomponent systems in the crystalline state using metal complexes of simple peptides, along with recent advances in the construction of giant artificial systems using short peptides.

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利用短柔性肽的结晶金属配合物构建的合作体系
生物系统通过涉及多个功能单元的复杂合作结构变化,显示出一系列人工系统无法完成的复杂功能。多肽的可设计性和结构灵活性是通过生物系统的协同结构变化来证明的;这些特性也使它们非常适合于形成显示这种变化的人工系统。使用肽框架的问题是,长肽残基不适合克级使用,是形成稳定有序结构所必需的。然而,如果能通过与金属离子配位来构建含肽的有序结构,肽将被广泛用于开发复杂的功能材料。晶体填充可以用于设计由简单分子制成的功能材料,因为它提供了一种将组件相互相对放置的方法。虽然晶体系统中已经报道了小尺寸的空腔归因于肽的柔韧性,但最近,具有巨大空腔的大型系统已经用柔性肽开发出来。本文综述了利用简单肽的金属配合物在晶体状态下形成协同多组分体系的研究进展,以及利用短肽构建巨大人工体系的最新进展。
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来源期刊
Journal of Inclusion Phenomena and Macrocyclic Chemistry
Journal of Inclusion Phenomena and Macrocyclic Chemistry Agricultural and Biological Sciences-Food Science
CiteScore
4.10
自引率
8.70%
发文量
54
期刊介绍: The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites. The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.
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