Amlodipine decreases mitral regurgitation volume in dogs over 7 days: A study of 24 dogs with myxomatous mitral valve degeneration.

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-04-05 eCollection Date: 2022-12-01 DOI:10.1002/vro2.33

Sool Yi Park, Won-Seok Oh, Seunggon Lee

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Abstract

Background: Amlodipine, a dihydropyridine calcium-channel blocker, is currently being investigated as a treatment for myxomatous mitral valvular degeneration (MMVD). However, the effects of amlodipine on moderate or severe spontaneous MMVD, based on changes in echocardiographic indices, remain unclear.

Animals: Client-owned small-breed dogs (n = 24) with naturally occurring MMVD of the American College of Veterinary Internal Medicine (ACVIM) stage B2 or higher.

Methods: Basic dog information including previous medication treatments were recorded. All subjects received amlodipine 0.1 mg/kg, administered per os, twice daily for 7 days, in addition to their existing medication. We measured systolic blood pressure, obtained x-ray, echocardiography, blood test data before and after 1 week of amlodipine administration.

Results: Left ventricular end-diastolic internal diameter, left atrial diameter and E wave reduced statistically after 1 week of amlodipine treatment (all p < 0.001). No adverse effects were reported.

Conclusions: These findings suggest that low-dose amlodipine should be considered as treatment for dogs with ACVIM stage B2‒C MMVD.

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氨氯地平减少犬二尖瓣返流量超过7天:24只犬二尖瓣黏液瘤变性的研究

摘要背景氨氯地平是一种二氢吡啶钙通道阻滞剂，目前正被研究用于治疗粘液瘤性二尖瓣退行性变（MMVD）。然而，根据超声心动图指标的变化，氨氯地平对中度或重度自发性MMVD的影响尚不清楚。动物客户拥有的小型犬（n=24），患有美国兽医学院（ACVIM）B2级或更高级别的自然发生的MMVD。方法记录犬的基本信息，包括既往用药情况。所有受试者除了现有药物外，还接受了0.1 mg/kg氨氯地平，每次口服，每天两次，持续7天。我们测量了氨氯地平给药1周前后的收缩压、x射线、超声心动图和血液测试数据。结果氨氯地平治疗1周后，左心室舒张末期内径、左心房直径和E波均有统计学意义的降低（均p＜0.001），无不良反应报告。结论这些发现表明，低剂量氨氯地平应被视为ACVIM B2-C期MMVD犬的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.