{"title":"In-situ bioprinting of skin - A review","authors":"Muhammad Salman Chaudhry, Aleksander Czekanski","doi":"10.1016/j.bprint.2023.e00271","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>The skin plays a vital role in several significant physiological functions, including wound healing. It is possible to regenerate the skin's epidermis and dermis layers using bio-printed skin substitutes </span>in patients<span> suffering from skin injuries. In-situ bioprinting has advanced significantly in recent years, enabling the usage of novel biomaterials and allowing the development of ‘biofabrication’ techniques that can resemble the biological, architectural, and functional complexity of native skin. This paper summarizes some of the most recent approaches to skin regeneration and in-situ bio-fabrication techniques. It also presents strategies and perspectives on triggering the proper regenerative response of the body through the tuned </span></span>mechanical properties<span> of the implant to recapitulate native physiology. Available materials for engineering ideal skin substitutes and reviewing the skin properties reported in the literature are also reported. Moreover, challenges and prospects in the clinical translation of in-situ bioprinting are also discussed.</span></p></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioprinting","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405886623000143","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Computer Science","Score":null,"Total":0}
引用次数: 2
Abstract
The skin plays a vital role in several significant physiological functions, including wound healing. It is possible to regenerate the skin's epidermis and dermis layers using bio-printed skin substitutes in patients suffering from skin injuries. In-situ bioprinting has advanced significantly in recent years, enabling the usage of novel biomaterials and allowing the development of ‘biofabrication’ techniques that can resemble the biological, architectural, and functional complexity of native skin. This paper summarizes some of the most recent approaches to skin regeneration and in-situ bio-fabrication techniques. It also presents strategies and perspectives on triggering the proper regenerative response of the body through the tuned mechanical properties of the implant to recapitulate native physiology. Available materials for engineering ideal skin substitutes and reviewing the skin properties reported in the literature are also reported. Moreover, challenges and prospects in the clinical translation of in-situ bioprinting are also discussed.
期刊介绍：
Bioprinting is a broad-spectrum, multidisciplinary journal that covers all aspects of 3D fabrication technology involving biological tissues, organs and cells for medical and biotechnology applications. Topics covered include nanomaterials, biomaterials, scaffolds, 3D printing technology, imaging and CAD/CAM software and hardware, post-printing bioreactor maturation, cell and biological factor patterning, biofabrication, tissue engineering and other applications of 3D bioprinting technology. Bioprinting publishes research reports describing novel results with high clinical significance in all areas of 3D bioprinting research. Bioprinting issues contain a wide variety of review and analysis articles covering topics relevant to 3D bioprinting ranging from basic biological, material and technical advances to pre-clinical and clinical applications of 3D bioprinting.
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