Synergistic antihyperglycemic effect of alpha lipoic acid with antidiabetic agents in the normoglycemic and streptozotocin-induced type 2 diabetic rats

IF 0.4 4区医学 Q4 PHARMACOLOGY & PHARMACY Acta poloniae pharmaceutica Pub Date : 2023-07-28 DOI:10.32383/appdr/166047

Rawsan Ali Sabri, B. Hameed, Falah Hassen Shari

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Abstract

The current study's main goal was to assess the supplementation effect of alpha lipoic acid with antidiabetic medications (metformin and sitagliptin) on normal and streptozotocin-induced blood glucose levels in normal and streptozotocin-induced diabetic rats. For this purpose, forty-two rats were randomly divided into two groups: normal control (n = 6) and diabetic (n = 36) groups, which were submitted to the following treatments: A: normal rats; B: diabetic rats; C: diabetic rats with sitagliptin (1 mg/kg); D: diabetic rats with metformin (10 mg/kg); E: diabetic rats with alpha lipoic acid (10 mg/kg); F: diabetic rats with a combination of alpha lipoic acid and sitagliptin; G: diabetic rats with a combination of alpha lipoic acid and metformin. The glycemia of these animals was monitored weekly; the use of alpha lipoic acid resulted in a significant decrease in glycemic levels. Combining alpha lipoic acid with either metformin or sitagliptin is most effective for reducing blood glucose levels in animals with acute and chronic hyperglycemia, even at different treatment times. Thus, associated with either metformin or sitagliptin, alpha lipoic acid improved their anti-diabetic effects.

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硫辛酸与降糖药对正常血糖及链霉素诱导的2型糖尿病大鼠的协同降糖作用

当前研究的主要目的是评估α硫辛酸与降糖药物(二甲双胍和西格列汀)对正常和链脲佐菌素诱导的糖尿病大鼠血糖水平的补充作用。为此，将42只大鼠随机分为正常对照组(n = 6)和糖尿病组(n = 36)，分别进行如下处理:A:正常大鼠;B:糖尿病大鼠;C:糖尿病大鼠西格列汀(1mg /kg);D:糖尿病大鼠给予二甲双胍(10 mg/kg);E:糖尿病大鼠α硫辛酸(10 mg/kg);F: α硫辛酸联合西格列汀治疗糖尿病大鼠;G:糖尿病大鼠与α硫辛酸和二甲双胍的组合。每周监测这些动物的血糖;硫辛酸的使用导致血糖水平显著下降。α硫辛酸与二甲双胍或西格列汀联合使用对降低急性和慢性高血糖动物的血糖水平最有效，即使在不同的治疗时间。因此，与二甲双胍或西格列汀联合使用，α硫辛酸可改善其抗糖尿病作用。

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来源期刊

Acta poloniae pharmaceutica 医学-药学

CiteScore

0.80

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The international journal of the Polish Pharmaceutical Society is published in 6 issues a year. The journal offers Open Access publication of original research papers, short communications and reviews written in English, in all areas of pharmaceutical sciences. The following areas of pharmaceutical sciences are covered: Analysis, Biopharmacy, Drug Biochemistry, Drug Synthesis, Natural Drugs, Pharmaceutical Technology, Pharmacology and General. A bimonthly appearing in English since 1994, which continues “Acta Poloniae Pharmaceutica”, whose first issue appeared in December 1937. The war halted the activity of the journal’s creators. Issuance of “Acta Poloniae Pharmaceutica” was resumed in 1947. From 1947 the journal appeared irregularly, initially as a quarterly, then a bimonthly. In the years 1963 – 1973 alongside the Polish version appeared the English edition of the journal. Starting from 1974 only works in English are published in the journal. Since 1995 the journal has been appearing very regularly in two-month intervals (six books a year). The journal publishes original works from all fields of pharmacy, summaries of postdoctoral dissertations and laboratory notes.